CA125 is a potential biomarker to predict surgically incurable gastric and cardia cancer: A retrospective study

Preoperative evaluation of the curability of gastric and cardia cancer is important to avoid risks of unnecessary surgery. Our previous study has reported several clinical parameters associated with incurable gastric surgery. In this study, we aimed to evaluate the correlation between CA125 and the...

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Bibliographic Details
Published in:Medicine (Baltimore) 2016-12, Vol.95 (51), p.e5297-e5297
Main Authors: Luo, Taobo, Chen, Wenhu, Wang, Lifang, Zhao, Hongguang
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
CA-125 Antigen - blood
Cardia - pathology
Female
Humans
Male
Membrane Proteins - blood
Middle Aged
Neoplasm Metastasis
Observational Study
Retrospective Studies
Risk Factors
ROC Curve
Stomach Neoplasms - blood
Stomach Neoplasms - diagnosis
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Treatment Failure
Young Adult
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Summary:Preoperative evaluation of the curability of gastric and cardia cancer is important to avoid risks of unnecessary surgery. Our previous study has reported several clinical parameters associated with incurable gastric surgery. In this study, we aimed to evaluate the correlation between CA125 and the curability of gastric and cardia cancer.A total of 297 cases of gastric and cardia cancer were analyzed retrospectively, including 153 cases with radical surgery and 144 with surgery for incurable gastric or cardia cancer. χ test was performed to analyze the associations between curability or incurable factors and clinicopathological data, including CA125 value. ROC curves were generated, and cutoff points for curability, T status, N status, peritoneal metastasis, and distant metastasis were found, respectively. Binary logistic regression was performed to verify the associations between dependent variables (curability, T status, N status, peritoneal metastasis, and distant metastasis) and covariates (related clinicopathological data from step 1 and cutoff points from step 2).Esophageal involvement, T grade, and CA125 were risk factors of curability. T grade and Borrmann type were risk factors of T status. T grade and CA125 were risk factors of N status. Age, esophageal involvement, T grade, and CA125 were risk factors of peritoneal metastasis. CA125 was risk factor of distant metastasis.CA125 is a potential biological marker for curability prediction of gastric and cardia cancer.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000005297