Prognostic Value of the Cumulative Cisplatin Dose During Concurrent Chemoradiotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma: A Secondary Analysis of a Prospective Phase III Clinical Trial

Background. The objective of this study was to evaluate the prognostic value of the cumulative cisplatin dose (CCD) for long‐term survival outcomes after concurrent chemoradiotherapy (CCRT) in locoregionally advanced nasopharyngeal carcinoma (NPC). Methods. Patients were included in an open‐label ph...

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Bibliographic Details
Published in:The oncologist (Dayton, Ohio) Ohio), 2016-11, Vol.21 (11), p.1369-1376
Main Authors: Peng, Hao, Chen, Lei, Zhang, Yuan, Li, Wen‐Fei, Mao, Yan‐Ping, Zhang, Fan, Guo, Rui, Liu, Li‐Zhi, Lin, Ai‐Hua, Sun, Ying, Ma, Jun
Format: Article
Language:English
Subjects:
Concurrent chemotherapy
Cumulative cisplatin dose
Head and Neck Cancer
Locoregionally advanced
Nasopharyngeal carcinoma
Prognosis
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Summary:Background. The objective of this study was to evaluate the prognostic value of the cumulative cisplatin dose (CCD) for long‐term survival outcomes after concurrent chemoradiotherapy (CCRT) in locoregionally advanced nasopharyngeal carcinoma (NPC). Methods. Patients were included in an open‐label phase III multicenter randomized controlled trial performed at seven institutions in China, and the 298 patients receiving CCRT only were assessed. Patient survival between different CCD groups were compared. Results. Median CCD for the 298 patients was 240 mg/m2 (range, 40–320 mg/m2); 113 (37.9%) patients received a CCD of
ISSN:1083-7159
1549-490X
DOI:10.1634/theoncologist.2016-0105