Vitamin D deficiency and airflow limitation in the Baltimore Longitudinal Study of Ageing

Background Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD) and has also been linked to comorbidities often present in COPD. Aim The aim of this study was to investigate whether vitamin D deficiency was related specifically to airflow limitation or whether...

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Bibliographic Details
Published in:European journal of clinical investigation 2015-09, Vol.45 (9), p.955-963
Main Authors: Moberg, Mia, Elango, Palchamy, Ferrucci, Luigi, Spruit, Martijn A., Wouters, Emiel F., Rutten, Erica P. A.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Airflow limitation
airway obstruction
Anemia - epidemiology
Baltimore - epidemiology
cardiovascular disease
Cohort Studies
comorbidities
Comorbidity
Cross-Sectional Studies
Female
Forced Expiratory Volume
Humans
Hypercholesterolemia - epidemiology
Hypertension - epidemiology
Insulin Resistance
Logistic Models
Longitudinal Studies
Male
Middle Aged
Obesity - epidemiology
physical activity
Prospective Studies
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - physiopathology
Risk Factors
Vital Capacity
vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
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Summary:Background Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD) and has also been linked to comorbidities often present in COPD. Aim The aim of this study was to investigate whether vitamin D deficiency was related specifically to airflow limitation or whether vitamin D deficiency was determined by conditions that frequently coexist with COPD: insulin resistance, hypertension, anaemia, obesity and hypercholesterolaemia. Methods For this cross‐sectional analysis, we included 897 subjects from the Baltimore Longitudinal Study of Aging. Subjects taking vitamin D supplements were excluded. Airflow limitation was defined as FEV1/FVC 
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.12498