Sonodynamic inactivation of Gram-positive and Gram-negative bacteria using a Rose Bengal–antimicrobial peptide conjugate

Highlights • Potential use of antimicrobial sonodynamic therapy (ASDT) as antibiotic-free treatment for localised infection. • Broad-spectrum efficacy of ASDT using a sensitiser–antimicrobial peptide hybrid. • In vivo demonstration of ASDT in a murine model of localised infection. • Ability of low-i...

Full description

Saved in:
Bibliographic Details
Published in:International journal of antimicrobial agents 2017-01, Vol.49 (1), p.31-36
Main Authors: Costley, David, Nesbitt, Heather, Ternan, Nigel, Dooley, James, Huang, Ying-Ying, Hamblin, Michael R, McHale, Anthony P, Callan, John F
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - pharmacology
Antimicrobial
Antimicrobial Cationic Peptides - pharmacology
Bacterial Load
Disease Models, Animal
Disinfection - methods
Fluorescent Dyes - pharmacology
Infectious Disease
Mice, Inbred BALB C
Peptide
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - radiation effects
Rose Bengal - pharmacology
Sensitiser
Sonodynamic therapy
Staphylococcus aureus - drug effects
Staphylococcus aureus - radiation effects
Ultrasonic Waves
Wound Infection - drug therapy
Wound Infection - microbiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Potential use of antimicrobial sonodynamic therapy (ASDT) as antibiotic-free treatment for localised infection. • Broad-spectrum efficacy of ASDT using a sensitiser–antimicrobial peptide hybrid. • In vivo demonstration of ASDT in a murine model of localised infection. • Ability of low-intensity ultrasound to enhance uptake of sensitisers in bacterial biofilms.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.09.034