Profiles of Inflammatory Cytokines in the Vitreous Fluid from Patients with Rhegmatogenous Retinal Detachment and Their Correlations with Clinical Features

Purpose. To characterize the profiles for inflammatory cytokines in the vitreous fluid from patients with rhegmatogenous retinal detachment (RRD) by comparing those of other vitreoretinal diseases and to analyze the correlation between intravitreal cytokines and clinical features. Materials and Meth...

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Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-9
Main Authors: Maeno, Atsuko, Suzuki, Yukihiko, Adachi, Kobu, Takahashi, Shizuka, Nakazawa, Mitsuru
Format: Article
Language:English
Subjects:
Aged
Chemokines
Cytokines
Cytokines - metabolism
Diabetic retinopathy
Female
Granulocytes
Humans
Inflammation Mediators - metabolism
Ischemia
Ligands
Male
Medical colleges
Medical records
Middle Aged
Pathogenesis
Patients
Photoreceptors
Proteins
Retina
Retinal detachment
Retinal Detachment - metabolism
Retinal Detachment - pathology
Retinal Detachment - surgery
Studies
Vascular endothelial growth factor
Vitreous Body - metabolism
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Summary:Purpose. To characterize the profiles for inflammatory cytokines in the vitreous fluid from patients with rhegmatogenous retinal detachment (RRD) by comparing those of other vitreoretinal diseases and to analyze the correlation between intravitreal cytokines and clinical features. Materials and Methods. Vitreous fluid was obtained at the time of surgery from 28 RRD eyes. Vitreous fluid was similarly collected from patients with macular hole (MH), epiretinal membrane, proliferative diabetic retinopathy (PDR), and retinal vein occlusion as controls. Twenty-seven cytokines were measured. Intravitreal cytokine profiles in RRD were characterized by comparing these with those in other vitreoretinal diseases. We also analyzed the correlations between vitreous cytokines and clinical features. Results. There were statistical differences in the MCP-1, MIP-1β, and IP-10 between the RRD and MH, while the IL-6 and IL-8 exhibited levels that were between those for the PDR and MH. MIP-1β was significantly correlated to both the extent and duration of the RRD, while IL-8 was significantly correlated to the extent of the RRD. Conclusions. MCP-1, MIP-1β, and IP-10 may modify the pathologic features of RRD. The levels of these cytokines are related in part to the clinical features and the level of photoreceptor damage.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/4256183