Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls

Highlights • Cortisol was not significantly correlated with HCV in MDDs or controls • DHEA(S) was positively correlated with HCV in MDDs but not in controls • Cortisol:DHEA(S) ratios were negatively correlated with HCV across MDDs and controls • It was hypothesized that cortisol effects on HCV may b...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-10, Vol.72, p.139-146
Main Authors: Jin, Rowen O, Mason, Sara, Mellon, Synthia H, Epel, Elissa S, Reus, Victor I, Mahan, Laura, Rosser, Rebecca L, Hough, Christina, Burke, Heather M, Mueller, Susanne G, Wolkowitz, Owen M
Format: Article
Language:English
Subjects:
Aged
Cortisol
Dehydroepiandrosterone (DHEA)
Dehydroepiandrosterone - blood
Dehydroepiandrosterone Sulfate - blood
Depression
Depressive Disorder, Major - diagnostic imaging
Depressive Disorder, Major - metabolism
Depressive Disorder, Major - pathology
DHEA sulfate (DHEAS)
Endocrinology & Metabolism
Female
Glucocorticoid
Healthy Volunteers
Hippocampal volume
Hippocampus
Hippocampus - anatomy & histology
Hippocampus - diagnostic imaging
Hippocampus - pathology
Humans
Hydrocortisone - blood
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI)
Major depressive disorder (MDD)
Male
Middle Aged
Pilot Projects
Psychiatry
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Summary:Highlights • Cortisol was not significantly correlated with HCV in MDDs or controls • DHEA(S) was positively correlated with HCV in MDDs but not in controls • Cortisol:DHEA(S) ratios were negatively correlated with HCV across MDDs and controls • It was hypothesized that cortisol effects on HCV may be modulated by DHEA(S).
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.06.017