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Methicillin-Resistant Staphylococcus aureus Biofilms and Their Influence on Bacterial Adhesion and Cohesion
Twenty-five methicillin-resistant Staphylococcus aureus (MRSA) isolates were characterized by staphylococcal protein A gene typing and the ability to form biofilms. The presence of exopolysaccharides, proteins, and extracellular DNA and RNA in biofilms was assessed by a dispersal assay. In addition,...
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| Published in: | BioMed research international 2016-01, Vol.2016 (2016), p.1-14 |
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| creator | Hun, Tan Geok Al-Obaidi, J. R. Neela, Vasantha Kumari Abdul Rahim, Raha Dakheel, Khulood Hamid Yusoff, Khatijah |
| description | Twenty-five methicillin-resistant Staphylococcus aureus (MRSA) isolates were characterized by staphylococcal protein A gene typing and the ability to form biofilms. The presence of exopolysaccharides, proteins, and extracellular DNA and RNA in biofilms was assessed by a dispersal assay. In addition, cell adhesion to surfaces and cell cohesion were evaluated using the packed-bead method and mechanical disruption, respectively. The predominant genotype was spa type t127 (22 out of 25 isolates); the majority of isolates were categorized as moderate biofilm producers. Twelve isolates displayed PIA-independent biofilm formation, while the remaining 13 isolates were PIA-dependent. Both groups showed strong dispersal in response to RNase and DNase digestion followed by proteinase K treatment. PIA-dependent biofilms showed variable dispersal after sodium metaperiodate treatment, whereas PIA-independent biofilms showed enhanced biofilm formation. There was no correlation between the extent of biofilm formation or biofilm components and the adhesion or cohesion abilities of the bacteria, but the efficiency of adherence to glass beads increased after biofilm depletion. In conclusion, nucleic acids and proteins formed the main components of the MRSA clone t127 biofilm matrix, and there seems to be an association between adhesion and cohesion in the biofilms tested. |
| doi_str_mv | 10.1155/2016/4708425 |
| format | article |
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R. ; Neela, Vasantha Kumari ; Abdul Rahim, Raha ; Dakheel, Khulood Hamid ; Yusoff, Khatijah</creator><contributor>Arciola, Carla R.</contributor><creatorcontrib>Hun, Tan Geok ; Al-Obaidi, J. R. ; Neela, Vasantha Kumari ; Abdul Rahim, Raha ; Dakheel, Khulood Hamid ; Yusoff, Khatijah ; Arciola, Carla R.</creatorcontrib><description>Twenty-five methicillin-resistant Staphylococcus aureus (MRSA) isolates were characterized by staphylococcal protein A gene typing and the ability to form biofilms. The presence of exopolysaccharides, proteins, and extracellular DNA and RNA in biofilms was assessed by a dispersal assay. In addition, cell adhesion to surfaces and cell cohesion were evaluated using the packed-bead method and mechanical disruption, respectively. The predominant genotype was spa type t127 (22 out of 25 isolates); the majority of isolates were categorized as moderate biofilm producers. Twelve isolates displayed PIA-independent biofilm formation, while the remaining 13 isolates were PIA-dependent. Both groups showed strong dispersal in response to RNase and DNase digestion followed by proteinase K treatment. PIA-dependent biofilms showed variable dispersal after sodium metaperiodate treatment, whereas PIA-independent biofilms showed enhanced biofilm formation. There was no correlation between the extent of biofilm formation or biofilm components and the adhesion or cohesion abilities of the bacteria, but the efficiency of adherence to glass beads increased after biofilm depletion. In conclusion, nucleic acids and proteins formed the main components of the MRSA clone t127 biofilm matrix, and there seems to be an association between adhesion and cohesion in the biofilms tested.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2016/4708425</identifier><identifier>PMID: 28078291</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aggregates ; Bacteria ; Bacterial Adhesion - drug effects ; Bacterial Adhesion - genetics ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; Biomedical research ; Biotechnology ; Cell adhesion ; Deoxyribonucleic acid ; DNA ; Enzymes ; Genes ; Humans ; Methicillin Resistance - drug effects ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - growth & development ; Microbial mats ; Nosocomial infections ; Observations ; Periodic Acid - pharmacology ; Physiological aspects ; Proteins ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - genetics ; Staphylococcal Infections - microbiology ; Staphylococcal Protein A - genetics ; Staphylococcal Protein A - metabolism ; Staphylococcus aureus ; Staphylococcus infections</subject><ispartof>BioMed research international, 2016-01, Vol.2016 (2016), p.1-14</ispartof><rights>Copyright © 2016 Khulood Hamid Dakheel et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Khulood Hamid Dakheel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Khulood Hamid Dakheel et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-ffea20f46ebb79f2ee416d62ab8285abff573f05302b7004d22f7acf977debd03</citedby><cites>FETCH-LOGICAL-c494t-ffea20f46ebb79f2ee416d62ab8285abff573f05302b7004d22f7acf977debd03</cites><orcidid>0000-0002-7683-4760 ; 0000-0002-5705-0223 ; 0000-0002-4076-8335</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1854578192/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1854578192?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28078291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Arciola, Carla R.</contributor><creatorcontrib>Hun, Tan Geok</creatorcontrib><creatorcontrib>Al-Obaidi, J. R.</creatorcontrib><creatorcontrib>Neela, Vasantha Kumari</creatorcontrib><creatorcontrib>Abdul Rahim, Raha</creatorcontrib><creatorcontrib>Dakheel, Khulood Hamid</creatorcontrib><creatorcontrib>Yusoff, Khatijah</creatorcontrib><title>Methicillin-Resistant Staphylococcus aureus Biofilms and Their Influence on Bacterial Adhesion and Cohesion</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Twenty-five methicillin-resistant Staphylococcus aureus (MRSA) isolates were characterized by staphylococcal protein A gene typing and the ability to form biofilms. The presence of exopolysaccharides, proteins, and extracellular DNA and RNA in biofilms was assessed by a dispersal assay. In addition, cell adhesion to surfaces and cell cohesion were evaluated using the packed-bead method and mechanical disruption, respectively. The predominant genotype was spa type t127 (22 out of 25 isolates); the majority of isolates were categorized as moderate biofilm producers. Twelve isolates displayed PIA-independent biofilm formation, while the remaining 13 isolates were PIA-dependent. Both groups showed strong dispersal in response to RNase and DNase digestion followed by proteinase K treatment. PIA-dependent biofilms showed variable dispersal after sodium metaperiodate treatment, whereas PIA-independent biofilms showed enhanced biofilm formation. There was no correlation between the extent of biofilm formation or biofilm components and the adhesion or cohesion abilities of the bacteria, but the efficiency of adherence to glass beads increased after biofilm depletion. 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R.</au><au>Neela, Vasantha Kumari</au><au>Abdul Rahim, Raha</au><au>Dakheel, Khulood Hamid</au><au>Yusoff, Khatijah</au><au>Arciola, Carla R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methicillin-Resistant Staphylococcus aureus Biofilms and Their Influence on Bacterial Adhesion and Cohesion</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Twenty-five methicillin-resistant Staphylococcus aureus (MRSA) isolates were characterized by staphylococcal protein A gene typing and the ability to form biofilms. The presence of exopolysaccharides, proteins, and extracellular DNA and RNA in biofilms was assessed by a dispersal assay. In addition, cell adhesion to surfaces and cell cohesion were evaluated using the packed-bead method and mechanical disruption, respectively. The predominant genotype was spa type t127 (22 out of 25 isolates); the majority of isolates were categorized as moderate biofilm producers. Twelve isolates displayed PIA-independent biofilm formation, while the remaining 13 isolates were PIA-dependent. Both groups showed strong dispersal in response to RNase and DNase digestion followed by proteinase K treatment. PIA-dependent biofilms showed variable dispersal after sodium metaperiodate treatment, whereas PIA-independent biofilms showed enhanced biofilm formation. There was no correlation between the extent of biofilm formation or biofilm components and the adhesion or cohesion abilities of the bacteria, but the efficiency of adherence to glass beads increased after biofilm depletion. In conclusion, nucleic acids and proteins formed the main components of the MRSA clone t127 biofilm matrix, and there seems to be an association between adhesion and cohesion in the biofilms tested.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28078291</pmid><doi>10.1155/2016/4708425</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-7683-4760</orcidid><orcidid>https://orcid.org/0000-0002-5705-0223</orcidid><orcidid>https://orcid.org/0000-0002-4076-8335</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | BioMed research international, 2016-01, Vol.2016 (2016), p.1-14 |
| issn | 2314-6133 2314-6141 |
| language | eng |
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| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); Wiley Online Library Open Access |
| subjects | Aggregates Bacteria Bacterial Adhesion - drug effects Bacterial Adhesion - genetics Biofilms Biofilms - drug effects Biofilms - growth & development Biomedical research Biotechnology Cell adhesion Deoxyribonucleic acid DNA Enzymes Genes Humans Methicillin Resistance - drug effects Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - growth & development Microbial mats Nosocomial infections Observations Periodic Acid - pharmacology Physiological aspects Proteins Staphylococcal Infections - drug therapy Staphylococcal Infections - genetics Staphylococcal Infections - microbiology Staphylococcal Protein A - genetics Staphylococcal Protein A - metabolism Staphylococcus aureus Staphylococcus infections |
| title | Methicillin-Resistant Staphylococcus aureus Biofilms and Their Influence on Bacterial Adhesion and Cohesion |
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