Thai Fruits Exhibit Antioxidant Activity and Induction of Antioxidant Enzymes in HEK-293 Cells

The cellular antioxidant enzymes play the important role of protecting the cells and organisms from the oxidative damage. Natural antioxidants contained in fruits have attracted considerable interest because of their presumed safety and potential nutritional value. Even though antioxidant activities...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2016-01, Vol.2016 (2016), p.1-14
Main Authors: Khammanit, Ruksinee, Praserttirachai, Wasin, Lomarat, Pattamapan, Anantachoke, Natthinee, Mangmool, Supachoke
Format: Article
Language:English
Subjects:
Acids
Antioxidants
Enzymes
Exhibitions
Flavonoids
Fruit
Fruits
Hydrogen peroxide
Oxidative stress
Pharmacy
Phytochemicals
Rodents
Sodium
Studies
Superoxide
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Summary:The cellular antioxidant enzymes play the important role of protecting the cells and organisms from the oxidative damage. Natural antioxidants contained in fruits have attracted considerable interest because of their presumed safety and potential nutritional value. Even though antioxidant activities of many fruits have been reported, the effects of phytochemicals contained in fruits on the induction of antioxidant enzymes in the cells have not been fully defined. In this study, we showed that extracts from Antidesma ghaesembilla, Averrhoa bilimbi, Malpighia glabra, Mangifera indica, Sandoricum koetjape, Syzygium malaccense, and Ziziphus jujuba inhibited H2O2-induced intracellular reactive oxygen species production in HEK-293 cells. Additionally, these Thai fruit extracts increased the mRNA and protein expressions of antioxidant enzymes, catalase, glutathione peroxidase-1, and manganese superoxide dismutase. The consumption of Thai fruits rich in phenolic compounds may reduce the risk of oxidative stress.
ISSN:1741-427X
1741-4288
DOI:10.1155/2016/6083136