Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression

Errors in chromosome segregation during mitosis have been recognized as a hallmark of tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic abnormalities drive tumorigenesis. Recent work has shown that mitotic defects can promote tumors, suppress them, or do neithe...

Full description

Saved in:
Bibliographic Details
Published in:Developmental cell 2016-12, Vol.39 (6), p.638-652
Main Authors: Funk, Laura C., Zasadil, Lauren M., Weaver, Beth A.
Format: Article
Language:English
Subjects:
Aneuploidy
Animals
Carcinogenesis - pathology
Chromosomal Instability
CIN
Humans
Mitosis
mitotic checkpoint
Models, Biological
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
spindle assembly checkpoint
Tumor Suppressor Protein p53 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Errors in chromosome segregation during mitosis have been recognized as a hallmark of tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic abnormalities drive tumorigenesis. Recent work has shown that mitotic defects can promote tumors, suppress them, or do neither, depending on the rate of chromosome missegregation. Here we discuss the causes of chromosome missegregation, their effects on tumor initiation and progression, and the evidence that increasing the rate of chromosome missegregation may be an effective chemotherapeutic strategy. Errors in chromosome segregation are a hallmark of tumor cells. Furthermore, how mitotic defects affect tumors depends on the rate of chromosome missegregation. Funk et al. discuss causes of chromosome missegregation, their effects on tumor initiation and progression, and whether increasing chromosome missegregation rates may be an effective chemotherapeutic strategy.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2016.10.023