Pharmacological Evaluation of Chrozophora tinctoria as Wound Healing Potential in Diabetic Rat’s Model

• Published in: BioMed research international 2016-01, Vol.2016 (2016), p.1-7
• Main Authors: Maurya, Harikesh, Dubey, Susheel Kumar, Semwal, Monika
• Format: Article
• Language: English
• Subjects: Animals; Blood Glucose; Chrozophora tinctoria; Collagen; Diabetes; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - pathology; Dicotyledons; Disease Models, Animal; Drug dosages; Euphorbiaceae - chemistry; Flavonoids; Health aspects; Humans; Iodine; Lipid peroxidation; Methods; Pharmacy; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Plant Leaves - chemistry; Rats; Rodents; Skin; Skin - drug effects; Skin - injuries; Skin - pathology; Streptozocin - toxicity; Wound healing; Wound Healing - drug effects
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2016/7475124

Objective. The study was designed to evaluate pharmacological potential of hydroalcoholic leaves extract of Chrozophora tinctoria intended for wound healing in diabetic rats’ model. Methods. The method used to evaluate the pharmacological potential of hydroalcoholic leave extract was physical incision rat model. In this model, cutting of the skin and/or other tissues with a sharp blade has been made and the rapid disruption of tissue integrity with minimal collateral damage was observed shortly. Animals used in the study were divided into four groups that consist of six animals in each group. Group I serves as normal control, Group II serves as disease control, Group III was used as standard treatment (Povidone iodine 50 mg/kg b.w.), and Group IV was used for test drug (C. tinctoria 50 mg/kg b.w.). Result. The hydroalcoholic leave extract of Chrozophora tinctoria has been significantly observed to heal the wound (98%) in diabetic rats within 21 days, while standard drug (Povidone iodine) healed the wound about 95% in the same condition. The oral dose (50 mg/kg b.w.) of Chrozophora tinctoria was also found to improve the elevated blood glucose level in comparison to disease control group, which increased after the oral administration of Streptozotocin. Conclusion. The Chrozophora tinctoria has significant wound healing potential in the animal having physically damaged tissue in diabetic condition.