Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity

Planar cell polarity (PCP)‐signaling and associated tissue polarization are evolutionarily conserved. A well documented feature of PCP‐signaling in vertebrates is its link to centriole/cilia positioning, although the relationship of PCP and ciliogenesis is still debated. A recent report in Drosophil...

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Bibliographic Details
Published in:BioEssays 2016-12, Vol.38 (12), p.1234-1245
Main Authors: Carvajal-Gonzalez, Jose Maria, Mulero-Navarro, Sonia, Mlodzik, Marek
Format: Article
Language:English
Subjects:
actin cytoskeleton
Animals
Cell Polarity
centriole/MTOC localization
Centrioles - physiology
cilia
Drosophila
Epithelial Cells - metabolism
Epithelial Cells - physiology
epithelial polarity
Frizzled Receptors - physiology
Frizzled-Vangl signaling
Insects
microtubules
planar cell polarity
Signal Transduction
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Summary:Planar cell polarity (PCP)‐signaling and associated tissue polarization are evolutionarily conserved. A well documented feature of PCP‐signaling in vertebrates is its link to centriole/cilia positioning, although the relationship of PCP and ciliogenesis is still debated. A recent report in Drosophila established that Frizzled (Fz)‐PCP core signaling has an instructive input to polarized centriole positioning in non‐ciliated Drosophila wing epithelia as a PCP read‐out. Here, we review the impact of this observation in the context of recent descriptions of the relationship(s) of core Fz‐PCP signaling and cilia/centriole positioning in epithelial and non‐epithelial cells. All existing data are consistent with a model where Fz‐PCP signaling functions upstream of centriole/cilia positioning, independent of ciliogenesis. The combined data sets indicate that the Fz‐Dsh PCP complex is instructive for centriole/ciliary positioning via an actin‐based mechanism. Thereby, centriole/cilia/centrosome positioning can be considered an evolutionarily conserved readout and common downstream effect of PCP‐signaling from flies to mammals. Centrioles/cilia and planar cell polarity (PCP) link is key for understanding many developmental, physiological and disease processes. Frizzled and its PCP signaling partners play a conserved role in positioning centrioles/basal bodies. Frizzled instructed positioning of centrioles was recently demonstrated to occur also in Drosophila, a prominent model to study PCP and centriole biogenesis.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.201600154