Locomotor Activity and the Expression of Orexin A and Orexin B in Aged Female Rhesus Macaques

Abstract Reduced activity has been linked to age-associated physiological changes but the underlying root cause is unclear. The goal of the present study was to compare the orexin neuronal system of old (23-29 years) female rhesus macaques with either active or sedentary 24-hour locomotor activity p...

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Bibliographic Details
Published in:Neurobiology of aging 2017-02, Vol.50, p.1-4
Main Authors: Luna, Selva L, Brown, Donald I, Eghlidi, Dominique H, Kohama, Steven G, Urbanski, Henryk F
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Aging - physiology
Animals
cFOS
Female
Hypocretin
Hypothalamic Area, Lateral - cytology
Hypothalamic Area, Lateral - metabolism
Hypothalamic Area, Lateral - pathology
Immunohistochemistry
Internal Medicine
Lateral hypothalamic area (LHA)
Macaca mulatta
Motor Activity - physiology
Neurology
Neurons - metabolism
Orexin
Orexins - metabolism
Rhesus macaque
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Summary:Abstract Reduced activity has been linked to age-associated physiological changes but the underlying root cause is unclear. The goal of the present study was to compare the orexin neuronal system of old (23-29 years) female rhesus macaques with either active or sedentary 24-hour locomotor activity patterns. Using immunohistochemistry we counted the number of orexin A and orexin B neurons in the lateral hypothalamic area (LHA) of each animal. Overall, we observed no difference in the distribution pattern or number of either orexin A or orexin B immune-positive neurons between animals in the two groups. Thus, reduced activity in the elderly is unlikely to stem from a loss of orexin neuronal perikarya in the LHA. This, however, does not rule out the possibility that the reduced activity stems from reduced orexin neuronal projections to arousal centers of the brain, such as the locus coeruleus, or from attenuated release of orexin.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2016.10.016