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Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents
To investigate the association of serum uric acid (SUA) with cardiometabolic abnormalities in Caucasian overweight/obese children (
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| Published in: | Italian journal of pediatrics 2017-01, Vol.43 (1), p.3-3, Article 3 |
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| container_title | Italian journal of pediatrics |
| container_volume | 43 |
| creator | Luciano, Rosa Shashaj, Blegina Spreghini, MariaRita Del Fattore, Andrea Rustico, Carmela Wietrzykowska Sforza, Rita Morino, Giuseppe Stefano Dallapiccola, Bruno Manco, Melania |
| description | To investigate the association of serum uric acid (SUA) with cardiometabolic abnormalities in Caucasian overweight/obese children ( |
| doi_str_mv | 10.1186/s13052-016-0321-0 |
| format | article |
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Cross-sectional evaluation of 1364 Caucasian overweight/obese patients (age 4.1-17.9 years; 726 males, 53%; 560 children, 41%).
SUA levels were significantly lower in children than in adolescents (4.74 ± 1.05 vs. 5.52 ± 1.49 mg/dl, p < 0.001) and peaked in 12-14 years-old boys and 10-12 years-old girls. In children with levels of SUA in the highest quartile (N = 75, 13%), OR for high triglycerides was 4.145, 95% CI 1.506-11.407 (p = 0.009). In adolescents with SUA in the highest quartile (N = 274, 34%), ORs for insulin resistance was 2.399 (95%CI 1.4-4.113; p < 0.001); for impaired fasting glucose 2.184 (95% CI 0.877-5.441; p = 0.07); for impaired glucose tolerance 2.390 (95% CI 1.405-4.063; p = 0.001); and for high triglycerides 1.8, (95%CI 0.950-3.420; p = 0.05). Multivariable random-effect linear regression models demonstrated that waist circumference and age (p < 0.0001 for both) are the variables most significantly predicting SUA levels, followed by triglycerides (p = 0.005) and 2 h glucose (p = 0.03) while HOMA-IR and BMI z-score did not predict SUA.
High uric acid is associated with metabolic abnormalities and particularly with waist circumference very early in childhood.</description><identifier>ISSN: 1824-7288</identifier><identifier>ISSN: 1720-8424</identifier><identifier>EISSN: 1824-7288</identifier><identifier>DOI: 10.1186/s13052-016-0321-0</identifier><identifier>PMID: 28049502</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Adolescent ; Biomarkers - blood ; Body Mass Index ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Incidence ; Italy - epidemiology ; Male ; Metabolic Syndrome - blood ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - etiology ; Pediatric Obesity - blood ; Pediatric Obesity - complications ; Pediatric Obesity - epidemiology ; Retrospective Studies ; Uric Acid - blood</subject><ispartof>Italian journal of pediatrics, 2017-01, Vol.43 (1), p.3-3, Article 3</ispartof><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-c3aa84459a0a3644842cabc8779a865f66272248ca0a8224d773e90c3d8c696b3</citedby><cites>FETCH-LOGICAL-c494t-c3aa84459a0a3644842cabc8779a865f66272248ca0a8224d773e90c3d8c696b3</cites><orcidid>0000-0002-6581-975X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209902/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1856115758?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28049502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luciano, Rosa</creatorcontrib><creatorcontrib>Shashaj, Blegina</creatorcontrib><creatorcontrib>Spreghini, MariaRita</creatorcontrib><creatorcontrib>Del Fattore, Andrea</creatorcontrib><creatorcontrib>Rustico, Carmela</creatorcontrib><creatorcontrib>Wietrzykowska Sforza, Rita</creatorcontrib><creatorcontrib>Morino, Giuseppe Stefano</creatorcontrib><creatorcontrib>Dallapiccola, Bruno</creatorcontrib><creatorcontrib>Manco, Melania</creatorcontrib><title>Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents</title><title>Italian journal of pediatrics</title><addtitle>Ital J Pediatr</addtitle><description>To investigate the association of serum uric acid (SUA) with cardiometabolic abnormalities in Caucasian overweight/obese children (<10 years of age) versus adolescents (≥10 years of age) by drawing age and gender specific percentiles of uric acid.
Cross-sectional evaluation of 1364 Caucasian overweight/obese patients (age 4.1-17.9 years; 726 males, 53%; 560 children, 41%).
SUA levels were significantly lower in children than in adolescents (4.74 ± 1.05 vs. 5.52 ± 1.49 mg/dl, p < 0.001) and peaked in 12-14 years-old boys and 10-12 years-old girls. In children with levels of SUA in the highest quartile (N = 75, 13%), OR for high triglycerides was 4.145, 95% CI 1.506-11.407 (p = 0.009). In adolescents with SUA in the highest quartile (N = 274, 34%), ORs for insulin resistance was 2.399 (95%CI 1.4-4.113; p < 0.001); for impaired fasting glucose 2.184 (95% CI 0.877-5.441; p = 0.07); for impaired glucose tolerance 2.390 (95% CI 1.405-4.063; p = 0.001); and for high triglycerides 1.8, (95%CI 0.950-3.420; p = 0.05). Multivariable random-effect linear regression models demonstrated that waist circumference and age (p < 0.0001 for both) are the variables most significantly predicting SUA levels, followed by triglycerides (p = 0.005) and 2 h glucose (p = 0.03) while HOMA-IR and BMI z-score did not predict SUA.
High uric acid is associated with metabolic abnormalities and particularly with waist circumference very early in childhood.</description><subject>Adolescent</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - etiology</subject><subject>Pediatric Obesity - blood</subject><subject>Pediatric Obesity - complications</subject><subject>Pediatric Obesity - epidemiology</subject><subject>Retrospective Studies</subject><subject>Uric Acid - blood</subject><issn>1824-7288</issn><issn>1720-8424</issn><issn>1824-7288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdUctqGzEUFaWhdtx-QDdB0E02k-g9mk0ghOYBhmTRrsUdjVzLzEiONBPo31dTp8HpRrroPK4OB6GvlFxQqtVlppxIVhGqKsIZrcgHtKSaiapmWn88mhfoNOcdKSSp6Ce0YJqIRhK2RLsnl6wLo-9dxnGDs0vTgKfkLQbrOwyhwxZS5-PgRmhjPwNtiGmA3o--iHzAsXXZ4YexPEHAduv7LrnwVwtdLM7zhvwZnWygz-7L671CP2-__7i5r9aPdw831-vKikaMleUAWgjZAAGuhNCCWWitrusGtJIbpVjNmNC24LoMXV1z1xDLO21Vo1q-QlcH3_3UDq6bdyfozT75AdJvE8Gb90jwW_MrvhjJSNMQVgzOXw1SfJ5cHs3gS4S-h-DilA3VUnLOasoL9dt_1F2cUijxZpaiVNZSFxY9sGyKOSe3efsMJWZu0hyaNKVJMzdZjhU6O07xpvhXHf8DL5qaaw</recordid><startdate>20170103</startdate><enddate>20170103</enddate><creator>Luciano, Rosa</creator><creator>Shashaj, Blegina</creator><creator>Spreghini, MariaRita</creator><creator>Del Fattore, Andrea</creator><creator>Rustico, Carmela</creator><creator>Wietrzykowska Sforza, Rita</creator><creator>Morino, Giuseppe Stefano</creator><creator>Dallapiccola, Bruno</creator><creator>Manco, Melania</creator><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6581-975X</orcidid></search><sort><creationdate>20170103</creationdate><title>Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents</title><author>Luciano, Rosa ; Shashaj, Blegina ; Spreghini, MariaRita ; Del Fattore, Andrea ; Rustico, Carmela ; Wietrzykowska Sforza, Rita ; Morino, Giuseppe Stefano ; Dallapiccola, Bruno ; Manco, Melania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-c3aa84459a0a3644842cabc8779a865f66272248ca0a8224d773e90c3d8c696b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - etiology</topic><topic>Pediatric Obesity - blood</topic><topic>Pediatric Obesity - complications</topic><topic>Pediatric Obesity - epidemiology</topic><topic>Retrospective Studies</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luciano, Rosa</creatorcontrib><creatorcontrib>Shashaj, Blegina</creatorcontrib><creatorcontrib>Spreghini, MariaRita</creatorcontrib><creatorcontrib>Del Fattore, Andrea</creatorcontrib><creatorcontrib>Rustico, Carmela</creatorcontrib><creatorcontrib>Wietrzykowska Sforza, Rita</creatorcontrib><creatorcontrib>Morino, Giuseppe Stefano</creatorcontrib><creatorcontrib>Dallapiccola, Bruno</creatorcontrib><creatorcontrib>Manco, Melania</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Italian journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luciano, Rosa</au><au>Shashaj, Blegina</au><au>Spreghini, MariaRita</au><au>Del Fattore, Andrea</au><au>Rustico, Carmela</au><au>Wietrzykowska Sforza, Rita</au><au>Morino, Giuseppe Stefano</au><au>Dallapiccola, Bruno</au><au>Manco, Melania</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents</atitle><jtitle>Italian journal of pediatrics</jtitle><addtitle>Ital J Pediatr</addtitle><date>2017-01-03</date><risdate>2017</risdate><volume>43</volume><issue>1</issue><spage>3</spage><epage>3</epage><pages>3-3</pages><artnum>3</artnum><issn>1824-7288</issn><issn>1720-8424</issn><eissn>1824-7288</eissn><abstract>To investigate the association of serum uric acid (SUA) with cardiometabolic abnormalities in Caucasian overweight/obese children (<10 years of age) versus adolescents (≥10 years of age) by drawing age and gender specific percentiles of uric acid.
Cross-sectional evaluation of 1364 Caucasian overweight/obese patients (age 4.1-17.9 years; 726 males, 53%; 560 children, 41%).
SUA levels were significantly lower in children than in adolescents (4.74 ± 1.05 vs. 5.52 ± 1.49 mg/dl, p < 0.001) and peaked in 12-14 years-old boys and 10-12 years-old girls. In children with levels of SUA in the highest quartile (N = 75, 13%), OR for high triglycerides was 4.145, 95% CI 1.506-11.407 (p = 0.009). In adolescents with SUA in the highest quartile (N = 274, 34%), ORs for insulin resistance was 2.399 (95%CI 1.4-4.113; p < 0.001); for impaired fasting glucose 2.184 (95% CI 0.877-5.441; p = 0.07); for impaired glucose tolerance 2.390 (95% CI 1.405-4.063; p = 0.001); and for high triglycerides 1.8, (95%CI 0.950-3.420; p = 0.05). Multivariable random-effect linear regression models demonstrated that waist circumference and age (p < 0.0001 for both) are the variables most significantly predicting SUA levels, followed by triglycerides (p = 0.005) and 2 h glucose (p = 0.03) while HOMA-IR and BMI z-score did not predict SUA.
High uric acid is associated with metabolic abnormalities and particularly with waist circumference very early in childhood.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>28049502</pmid><doi>10.1186/s13052-016-0321-0</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6581-975X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1824-7288 |
| ispartof | Italian journal of pediatrics, 2017-01, Vol.43 (1), p.3-3, Article 3 |
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| subjects | Adolescent Biomarkers - blood Body Mass Index Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Child Child, Preschool Cross-Sectional Studies Female Humans Incidence Italy - epidemiology Male Metabolic Syndrome - blood Metabolic Syndrome - epidemiology Metabolic Syndrome - etiology Pediatric Obesity - blood Pediatric Obesity - complications Pediatric Obesity - epidemiology Retrospective Studies Uric Acid - blood |
| title | Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents |
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