Optimal Control Model of Tumor Treatment with Oncolytic Virus and MEK Inhibitor

Tumors are a serious threat to human health. The oncolytic virus is a kind of tumor killer virus which can infect and lyse cancer cells and spread through the tumor, while leaving normal cells largely unharmed. Mathematical models can help us to understand the tumor-virus dynamics and find better tr...

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Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-8
Main Authors: Su, Yongmei, Chen, Ying, Jia, Chen
Format: Article
Language:English
Subjects:
Adenoviruses
Cancer
Cancer therapies
Care and treatment
Cell cycle
Chinese medicine
Equilibrium
Humans
Infections
Kinases
Mathematical models
Mitogen-Activated Protein Kinases - antagonists & inhibitors
Models, Theoretical
Neoplasms - genetics
Neoplasms - therapy
Neoplasms - virology
Oncolytic Virotherapy
Oncolytic Viruses - genetics
Pharmaceutical industry
Protein Kinase Inhibitors - therapeutic use
Tumors
Virus Replication - drug effects
Viruses
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Summary:Tumors are a serious threat to human health. The oncolytic virus is a kind of tumor killer virus which can infect and lyse cancer cells and spread through the tumor, while leaving normal cells largely unharmed. Mathematical models can help us to understand the tumor-virus dynamics and find better treatment strategies. This paper gives a new mathematical model of tumor therapy with oncolytic virus and MEK inhibitor. Stable analysis was given. Because mitogen-activated protein kinase (MEK) can not only lead to greater oncolytic virus infection into cancer cells, but also limit the replication of the virus, in order to provide the best dosage of MEK inhibitors and balance the positive and negative effect of the inhibitors, we put forward an optimal control problem of the inhibitor. The optimal strategies are given by theory and simulation.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/5621313