POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins

We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR su...

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Bibliographic Details
Published in:Nucleic acids research 2017-01, Vol.45 (D1), p.D104-D114
Main Authors: Hu, Boqin, Yang, Yu-Cheng T, Huang, Yiming, Zhu, Yumin, Lu, Zhi John
Format: Article
Language:English
Subjects:
Alternative Splicing
Animals
Binding Sites
Database Issue
Databases, Genetic
Disease - genetics
Gene Ontology
Humans
Mice
MicroRNAs - metabolism
Molecular Sequence Annotation
Nucleic Acid Conformation
Polymorphism, Single Nucleotide
RNA - chemistry
RNA - metabolism
RNA Processing, Post-Transcriptional
RNA-Binding Proteins - metabolism
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Summary:We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR supplies the largest collection of experimentally probed (∼23 million) and computationally predicted (approximately 117 million) RBP binding sites in the human and mouse transcriptomes. POSTAR annotates every transcript and its RBP binding sites using extensive information regarding various molecular regulatory events (e.g., splicing, editing, and modification), RNA secondary structures, disease-associated variants, and gene expression and function. Moreover, POSTAR provides a friendly, multi-mode, integrated search interface, which helps users to connect multiple RBP binding sites with post-transcriptional regulatory events, phenotypes, and diseases. Based on our platform, we were able to obtain novel insights into post-transcriptional regulation, such as the putative association between CPSF6 binding, RNA structural domains, and Li-Fraumeni syndrome SNPs. In summary, POSTAR represents an early effort to systematically annotate post-transcriptional regulatory maps and explore the putative roles of RBPs in human diseases.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkw888