Overviews of biological importance of quercetin: A bioactive flavonoid

Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables. The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, m...

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Bibliographic Details
Published in:Pharmacognosy reviews 2016-07, Vol.10 (20), p.84-89
Main Authors: Anand David, Alexander, Arulmoli, Radhakrishnan, Parasuraman, Subramani
Format: Article
Language:English
Subjects:
Alcohol
Antioxidants
Antioxidants (Nutrients)
Blood lipids
Cancer
Cancer prevention
Cardiovascular disease
Cardiovascular diseases
Chronic obstructive pulmonary disease
Citrus
Clinical trials
Conflicts of interest
Diabetes
Dietary supplements
Flavonoids
Free radicals
Fruits
Hypertension
Infections
Inflammation
Inflammatory diseases
Isoflavones
Medical research
Metabolism
Metabolites
Neurophysiology
Oxidation
Oxidative stress
Physiological aspects
Review
Vasodilator agents
Vegetables
Water pollution
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Summary:Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables. The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, metabolic disorders, and certain types of cancer. These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins oxidation and platelet aggregation, and acting as vasodilators in blood vessels. Free radicals are constantly generated resulting in extensive damage to tissues leading to various disease conditions such as cancer, Alzheimer's, renal diseases, cardiac abnormalities, etc., Medicinal plants with antioxidant properties play a vital functions in exhibiting beneficial effects and employed as an alternative source of medicine to mitigate the disease associated with oxidative stress. Flavonoids have existed over one billion years and possess wide spectrum of biological activities that might be able to influence processes which are dysregulated in a disease. Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits. It is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.
ISSN:0973-7847
0976-2787
DOI:10.4103/0973-7847.194044