Reduction in incomplete stent apposition area caused by jailed struts after single stenting at left main bifurcation lesions: micro-CT analysis using a three-dimensional elastic bifurcated coronary artery model

• Published in: Cardiovascular intervention and therapeutics 2017-01, Vol.32 (1), p.12-17
• Main Authors: Hikichi, Yutaka, Umezu, Mitsuo, Node, Koichi, Iwasaki, Kiyotaka
• Format: Article
• Language: English
• Subjects: Cardiology; Coronary Angiography - methods; Coronary Stenosis - diagnosis; Coronary Stenosis - surgery; Coronary Vessels - diagnostic imaging; Coronary Vessels - surgery; Drug-Eluting Stents; Humans; Imaging, Three-Dimensional; Interventional Radiology; Medicine; Medicine & Public Health; Multidetector Computed Tomography - methods; Original; Original Article; Prosthesis Design; X-Ray Microtomography - methods
• ISSN: 1868-4300; 1868-4297
• DOI: 10.1007/s12928-016-0380-6

Stent struts protruding into ostial side branch called “jailed strut” at bifurcation lesions is a likely cause of thrombus formation. We aimed to investigate the influences of multiple kissing balloon inflation (KBI) for stent expansion, and stent platform design, respectively, on the reduction of incomplete stent apposition area (ISA area) caused by jailed struts at a side-branch ostium, using a three-dimensional elastic left main (LM) bifurcated coronary artery model. The referenced LM bifurcation angle data of 209 patients were stratified by tertiles focusing on the angle between the LM trunk (LMT) and left anterior descending artery (LAD). A bifurcation model was fabricated with angles of 129°, 122.2°, and 76.4° for LMT–LAD, LMT–left circumflex (LCx), and LAD–LCx, respectively, and with diameters of 5, 3.75, and 3.5 mm for LMT, LAD, and LCx, respectively; these diameters fulfill Murray’s law. A 75 % stenosis was included along the LMT. One-time and three-time KBIs were conducted using two-link Nobori and three-link Xience Xpedition ( n  = 6 each). The ISA area was quantified using micro-CT. Three-time KBI was effective in reducing the ISA area compared with one-time KBI for both the Nobori ( p  = 0.05) and Xience Xpedition ( p  = 0.07). The ISA area was smaller in the Nobori than in the Xience Xpedition, both in one-time and three-time KBI (one-time KBI: p  = 0.003; three-time KBI: p  = 0.001). Our findings of this study on reducing the ISA area by focusing on an interventional technique and stent design may help to improve coronary bifurcation intervention for a possibly better long-term clinical outcome.