N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma

OBJECTIVE:To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA). METHODS:The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed using a 5′-nuclease polymerase chain reaction assay. RESULTS:The NAT...

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Published in:Journal of occupational and environmental medicine 2015-12, Vol.57 (12), p.1331-1336
Main Authors: Yucesoy, Berran, Kissling, Grace E., Johnson, Victor J., Lummus, Zana L., Gautrin, Denyse, Cartier, André, Boulet, Louis-Philippe, Sastre, Joaquin, Quirce, Santiago, Tarlo, Susan M., Cruz, Maria-Jesus, Munoz, Xavier, Luster, Michael I., Bernstein, David I.
Format: Article
Language:English
Subjects:
Adult
Arylamine N-Acetyltransferase - genetics
Asthma
Asthma, Occupational - chemically induced
Asthma, Occupational - genetics
Canada
Environmental Pollutants - toxicity
Enzymes
Female
Genes
Genetic Markers
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Genotyping Techniques
Humans
Isocyanates - toxicity
Logistic Models
Male
Middle Aged
Original Article
Polymerase chain reaction
Polymorphism, Single Nucleotide
Regression analysis
Spain
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Summary:OBJECTIVE:To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA). METHODS:The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed using a 5′-nuclease polymerase chain reaction assay. RESULTS:The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in the univariate analysis. In the first logistic regression model comparing DA+ and asymptomatic worker groups, the rs2410556 (P = 0.004) and rs4271002 (P 
ISSN:1076-2752
1536-5948
1536-5948
DOI:10.1097/JOM.0000000000000561