Effectiveness of regionally-specific immunotherapy for the management of canine atopic dermatitis

Canine atopic dermatitis is a common pruritic skin disease often treated with allergen immunotherapy (AIT). AIT in dogs traditionally begins with attempting to identify clinically relevant environmental allergens. Current allergen testing methodologies and immunotherapy techniques in dogs are not st...

Full description

Saved in:
Bibliographic Details
Published in:BMC veterinary research 2017-01, Vol.13 (1), p.4-4, Article 4
Main Authors: Plant, Jon D, Neradilek, Moni B
Format: Article
Language:English
Subjects:
aerobiology
allergenicity
allergens
Allergens - immunology
Animals
atopic dermatitis
blood serum
Care and treatment
Dermatitis
Dermatitis, Atopic - immunology
Dermatitis, Atopic - therapy
Dermatitis, Atopic - veterinary
Desensitization, Immunologic - veterinary
Dog diseases
Dog Diseases - immunology
Dog Diseases - therapy
Dogs
drug therapy
Immunotherapy
Immunotherapy, Active - veterinary
Methods
pruritus
Retrospective Studies
veterinary medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Canine atopic dermatitis is a common pruritic skin disease often treated with allergen immunotherapy (AIT). AIT in dogs traditionally begins with attempting to identify clinically relevant environmental allergens. Current allergen testing methodologies and immunotherapy techniques in dogs are not standardized. Immunotherapy with a mixture of allergenic extracts selected based on regional aerobiology rather than intradermal tests or serum IgE assays has been described. The objective of this study was to evaluate the effectiveness of regionally-specific immunotherapy in dogs with atopic dermatitis. The medical records of a veterinary dermatology referral clinic were searched for dogs with atopic dermatitis that began regionally-specific subcutaneous immunotherapy from June, 2010 to May, 2013. An overall assessment of treatment effectiveness (excellent, good, fair, or poor) was assigned based upon changes in pruritus severity, lesion severity, and the reduction in concurrent medication(s) during a follow-up period of at least 270 days. Baseline characteristics that might predict treatment success were analyzed with the Spearman's correlation and the Kruskal-Wallis tests. Of the 286 dogs that began regionally-specific immunotherapy (RESPIT) during a 3 year period, 103 met the inclusion criteria. The overall response to RESPIT was classified as excellent in 19%, good in 38%, fair in 25%, and poor in 18% of dogs. The response classification correlated significantly with a reduction in pruritus severity (r = 0.72, p 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-016-0917-z