Differential expression of genes related to gain and intake in the liver of beef cattle

To better understand which genes play a role in cattle feed intake and gain, we evaluated differential expression of genes related to gain and intake in the liver of crossbred beef steers. Based on past transcriptomics studies on cattle liver, we hypothesized that genes related to metabolism regulat...

Full description

Saved in:
Bibliographic Details
Published in:BMC research notes 2017-01, Vol.10 (1), p.1-1, Article 1
Main Authors: Zarek, C M, Lindholm-Perry, A K, Kuehn, L A, Freetly, H C
Format: Article
Language:English
Subjects:
Animals
beef cattle
biochemical pathways
Cattle - genetics
cattle feeds
chemokines
Chemokines - metabolism
crossbreds
feed conversion
feed intake
gene expression
Gene Expression Profiling
Gene Expression Regulation
genes
Humans
immune response
Immune System
Inflammation
liver
Liver - metabolism
Male
Oligonucleotide Array Sequence Analysis
Oxidative Stress
Phenotype
physiological transport
proteasome endopeptidase complex
Proteasome Endopeptidase Complex - metabolism
RNA - analysis
Signal Transduction
transcriptomics
Ubiquitination
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To better understand which genes play a role in cattle feed intake and gain, we evaluated differential expression of genes related to gain and intake in the liver of crossbred beef steers. Based on past transcriptomics studies on cattle liver, we hypothesized that genes related to metabolism regulation and the inflammatory response would be differentially expressed. This study used 16 animals with diverse gain and intake phenotypes to compare transcript abundance after a 78 day ad libitum feed study. A total of 729 genes were differentially expressed. These genes were analyzed for over-representation among biological and cellular functions, and pathways. Cell transport processes and metabolic processes, as well as functions related to transport, were identified. Pathways related to immune function, such as the proteasome ubiquitination pathway and the chemokine signaling pathway, were also identified. Our results were consistent with past transcriptomics studies that have found immune and transport processes play a role in feed efficiency. Gain and intake are impacted by complex processes in the liver, which include cellular transport, metabolism regulation, and immune function.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-016-2345-3