Gender differences in sudden cardiac death in the young-a nationwide study

Hitherto, sudden cardiac death (SCD) in the young has been described with no distinction between genders. SCD occurs more often in men (SCDm) than women (SCDw), but this disparity is not understood and has not been investigated systematically in a nationwide setting. Our objective was to report gend...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2017-01, Vol.17 (1), p.19-19, Article 19
Main Authors: Winkel, Bo Gregers, Risgaard, Bjarke, Bjune, Thea, Jabbari, Reza, Lynge, Thomas Hadberg, Glinge, Charlotte, Bundgaard, Henning, Haunsø, Stig, Tfelt-Hansen, Jacob
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Distribution
Analysis
Cardiovascular disease
Cause of Death
Child
Child, Preschool
Comorbidity
Death, Sudden, Cardiac - epidemiology
Demographic aspects
Denmark - epidemiology
Ethics
Female
Forensic pathology
Gender differences
Hospitals
Humans
Incidence
Infant
Infant, Newborn
Investigations
Male
Males
Mens health
Registries
Retrospective Studies
Risk Factors
Sex Distribution
Studies
Sudden cardiac death
Time Factors
Womens health
Young Adult
Young adults
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Summary:Hitherto, sudden cardiac death (SCD) in the young has been described with no distinction between genders. SCD occurs more often in men (SCDm) than women (SCDw), but this disparity is not understood and has not been investigated systematically in a nationwide setting. Our objective was to report gender differences in SCD in the young in a nationwide (Denmark) setting. All deaths in persons aged 1-35 years nationwide in Denmark between 2000 and 2009 were included. Death certificates and autopsy reports were obtained. The extensive health care registries in Denmark were used to investigate any known disease prior to death. SCDw were compared to SCDm. During the 10-year study period there were a total of 8756 deaths in 23.7 million person-years. In total, 635 deaths were SCD. SCDw constituted 205 deaths (32%). Women had a higher proportion of witnessed deaths (51 vs. 41%, p = 0.02) and died less often in a public place (16 vs. 26%, p = 0.01). Age at death, ratios of autopsies and sudden unexplained deaths, and comorbidities, did not differ. Causes of SCD were largely comparable between genders. The incidence rate of SCDw was half of that of SCDm (1.8 vs. 3.6 per 100,000 person-years, incidence rate ratio 2.0 (95% CI 1.7-2.4), p 
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-016-0446-5