MicroRNA profiling in clear cell renal cell carcinoma tissues potentially links tumorigenesis and recurrence with obesity

Background: Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. Methods: Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t -test was used...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2017-01, Vol.116 (1), p.77-84
Main Authors: Shu, X, Hildebrandt, M A, Gu, J, Tannir, N M, Matin, S F, Karam, J A, Wood, C G, Wu, X
Format: Article
Language:English
Subjects:
631/337/384/331
692/4028/67/589/1588/1351
692/420/755
692/699/2743/393
Biomarkers
Biomedical and Life Sciences
Biomedicine
Body mass index
Cancer Research
Carcinogenesis - genetics
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - pathology
Drug Resistance
Epidemiology
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genomes
Humans
Kidney cancer
Kidney Neoplasms - genetics
Kidney Neoplasms - pathology
Male
Medical prognosis
Medical research
MicroRNAs
MicroRNAs - genetics
Molecular Diagnostics
Molecular Medicine
Neoplasm Recurrence, Local - genetics
Obesity
Obesity - complications
Obesity - genetics
Oligonucleotide Array Sequence Analysis
Oncology
Patients
Reproducibility of Results
Smoking
Transcriptome
Tumorigenesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. Methods: Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t -test was used for tumour–normal comparisons and Cox regression model was performed to compute hazard ratios (HRs) and corresponding 95% CIs. Results: A 17-miRNA signature was identified that can concordantly classify >95% of tumour/adjacent normal samples. Significant enrichment was found as 6 out of 17 miRNAs were associated with obesity (binomial probability=0.001). Decreased levels of miR-204-5p and miR-139-5p were each associated with an approximately three-fold increased risk of recurrence ( P 70.3 months). Expressions of miR-204-5p were also associated with body mass index ( β =5.64, P
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2016.392