Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide

The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50 ng/L glyphosate equivalent dilution; 4 ng/kg body weight/day daily inta...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2017-01, Vol.7 (1), p.39328, Article 39328
Main Authors: Mesnage, Robin, Renney, George, Séralini, Gilles-Eric, Ward, Malcolm, Antoniou, Michael N.
Format: Article
Language:English
Subjects:
631/337/475
692/4020/4021/1607/2750
Animals
Ascorbic acid
Body weight
Chronic exposure
Disease Models, Animal
Fatty liver
Gene expression
Glutathione
Glycine - analogs & derivatives
Glycine - toxicity
Glyphosate
Hepatotoxicity
Herbicides
Herbicides - toxicity
Humanities and Social Sciences
Liver
Liver - pathology
Liver diseases
Metabolites
Metabolomics
multidisciplinary
Non-alcoholic Fatty Liver Disease - chemically induced
Non-alcoholic Fatty Liver Disease - pathology
Oxidative stress
Proline
Proteomes
Proteomics
Rats
Rodents
Science
Steatosis
Urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50 ng/L glyphosate equivalent dilution; 4 ng/kg body weight/day daily intake) of a Roundup GBH formulation showed signs of enhanced liver injury as indicated by anatomorphological, blood/urine biochemical changes and transcriptome profiling. Here we present a multiomic study combining metabolome and proteome liver analyses to obtain further insight into the Roundup-induced pathology. Proteins significantly disturbed (214 out of 1906 detected, q 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep39328