Deregulated Cardiac Specific MicroRNAs in Postnatal Heart Growth

The heart is recognized as an organ that is terminally differentiated by adulthood. However, during the process of human development, the heart is the first organ with function in the embryo and grows rapidly during the postnatal period. MicroRNAs (miRNAs, miRs), as regulators of gene expression, pl...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-6
Main Authors: Yao, Jianhua, Zhou, Jinzhe, Xie, Yuan, Wang, Hongbao, Yu, Pujiao, Che, Lin
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biomedical research
Cardiology
Embryonic development
Female
Gene expression
Gene Expression Regulation - physiology
Genetic aspects
Growth
Heart
Heart - growth & development
Hospitals
Humans
Laboratory animals
Male
Mice
MicroRNA
MicroRNAs
MicroRNAs - biosynthesis
Ontology
Physiological aspects
Rodents
Roles
Software
Stem cells
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The heart is recognized as an organ that is terminally differentiated by adulthood. However, during the process of human development, the heart is the first organ with function in the embryo and grows rapidly during the postnatal period. MicroRNAs (miRNAs, miRs), as regulators of gene expression, play important roles during the development of multiple systems. However, the role of miRNAs in postnatal heart growth is still unclear. In this study, by using qRT-PCR, we compared the expression of seven cardiac- or muscle-specific miRNAs that may be related to heart development in heart tissue from mice at postnatal days 0, 3, 8, and 14. Four miRNAs—miR-1a-3p, miR-133b-3p, miR-208b-3p, and miR-206-3p—were significantly decreased while miR-208a-3p was upregulated during the postnatal heart growth period. Based on these results, GeneSpring GX was used to predict potential downstream targets by performing a 3-way comparison of predictions from the miRWalk, PITA, and microRNAorg databases. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were used to identify potential functional annotations and signaling pathways related to postnatal heart growth. This study describes expression changes of cardiac- and muscle-specific miRNAs during postnatal heart growth and may provide new therapeutic targets for cardiovascular diseases.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/6241763