Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive ag...

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Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-17
Main Authors: Espinosa-Aguirre, Jesús Javier, del Rosario Olguín-Reyes, Sitlali, Hernández-Magaña, Alexis, Marroquín-Pérez, Ana, Cabañas, Noel, Ornelas-Ayala, Diego, Santes, Rebeca, Camacho-Carranza, Rafael
Format: Article
Language:English
Subjects:
Biomedical research
Cancer
Chemotherapy
Cytochrome
Cytochrome P-450
Cytochrome P-450 CYP1A1 - metabolism
Deoxyribonucleic acid
DNA
Enzymes
Gene expression
Health aspects
Humans
Hydrocarbons
Ligands
Metabolism
Metabolites
Methods
Neoplasm Proteins - metabolism
Phylogenetics
Precancerous Conditions - enzymology
Proteins
Review
Rodents
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Summary:Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive agents. The aim of this work is to review the origin, regulation, and structural and functional characteristics of CYP1A1 letting us understand its role in the bioactivation of precarcinogen and the consequences of its modulation in other physiological processes, as well as guide us in the study of this important protein.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/5341081