Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model

Ginsenosides, which are the active materials of ginseng, have biological functions that include anti-osteoporotic effects. Aqueous ginseng extract inhibits osteoclast differentiation induced by receptor activator of NF-κB ligand (RANKL). Aqueous ginseng extract produces chromatography peaks characte...

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Bibliographic Details
Published in:Molecules and cells 2016-12, Vol.39 (12), p.855-861
Main Authors: Park, Chan-Mi, Kim, Hye-Min, Kim, Dong Hyun, Han, Ho-Jin, Noh, Haneul, Jang, Jae-Hyuk, Park, Soo-Hyun, Chae, Han-Jung, Chae, Soo-Wan, Ryu, Eun Kyoung, Lee, Sangku, Liu, Kangdong, Liu, Haidan, Ahn, Jong-Seog, Kim, Young Ock, Kim, Bo-Yeon, Soung, Nak-Kyun
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - cytology
Bone Marrow Cells - drug effects
Cell Differentiation - drug effects
Ginsenosides - pharmacology
Macrophages - cytology
Macrophages - drug effects
Mice
Osteoclasts - cytology
Osteoclasts - drug effects
Zebrafish
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Summary:Ginsenosides, which are the active materials of ginseng, have biological functions that include anti-osteoporotic effects. Aqueous ginseng extract inhibits osteoclast differentiation induced by receptor activator of NF-κB ligand (RANKL). Aqueous ginseng extract produces chromatography peaks characteristic of ginsenosides. Among these peaks, ginsenoside Re is a major component. However, the preventive effects of ginsenoside Re against osteoclast differentiation are not known. We studied the effect of ginsenoside Re on osteoclast differentiation, RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity, and formation of multinucleated osteoclasts . Ginsenoside Re hampered osteoclast differentiation in a dose-dependent manner In an ebrafish model, aqueous ginseng extract and ginsenoside Re had anti-osteoclastogenesis effects. These findings suggest that both aqueous ginseng extract and ginsenoside Re prevent bone resorption by inhibiting osteoclast differentiation. Ginsenoside Re could be important for promoting bone health.
ISSN:1016-8478
0219-1032
DOI:10.14348/molcells.2016.0111