Monitoring of adherence to headache treatments by means of hair analysis

Purpose The aim of this study was to evaluate the potential of hair analysis to monitor medication adherence in headache patients undergoing chronic therapy. For this purpose, the following parameters were analyzed: the detection rate of 23 therapeutic drugs in headache patients’ hair, the degree of...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 2017-02, Vol.73 (2), p.197-203
Main Authors: Ferrari, Anna, Licata, Manuela, Rustichelli, Cecilia, Baraldi, Carlo, Vandelli, Daniele, Marchesi, Filippo, Palazzoli, Federica, Verri, Patrizia, Silingardi, Enrico
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Compliance
Drug Monitoring - methods
Drug therapy
Female
Hair - chemistry
Hair analysis
Headache - drug therapy
Headaches
Humans
Male
Medication Adherence
Middle Aged
Pharmaceutical Preparations - analysis
Pharmacokinetics and Disposition
Pharmacology/Toxicology
Self Report
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The aim of this study was to evaluate the potential of hair analysis to monitor medication adherence in headache patients undergoing chronic therapy. For this purpose, the following parameters were analyzed: the detection rate of 23 therapeutic drugs in headache patients’ hair, the degree of agreement between the self-reported drug and the drug found in hair, and whether the levels found in hair reflected the drug intake reported by the patients. Methods The study included 93 patients suffering from primary headaches declaring their daily intake of at least one of the following drugs during the 3 months before the hair sampling: alprazolam, amitriptyline, citalopram, clomipramine, clonazepam, delorazepam, diazepam, duloxetine, fluoxetine, flurazepam, levomepromazine, levosulpiride, lorazepam, lormetazepam, mirtazapine, paroxetine, quetiapine, sertraline, topiramate, trazodone, triazolam, venlafaxine, and zolpidem. A detailed pharmacological history and a sample of hair were collected for each patient. Hair samples were analyzed by liquid chromatography-electrospray tandem mass spectrometry, using a previously developed method. Results All 23 drugs were detected in the examined hair samples. The agreement between the self-reported drug and the drug found in hair was excellent for most analytes ( P  
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-016-2163-5