Applicability of rapid intraoperative parathyroid hormone assay through fine needle aspiration to identify parathyroid tissue in thyroid surgery

Hypoparathyroidism is a frequent and serious complication of thyroid surgery. Identification and preservation of the parathyroid glands are key factors in managing hypoparathyroidism. The aim of the present study was to investigate the efficacy of rapid intraoperative parathyroid hormone (rIO-PTH) a...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2016-12, Vol.12 (6), p.4072-4076
Main Authors: Bian, Xue-Hai, Li, Shi-Jie, Zhou, Le, Zhang, Chun-Hai, Zhang, Guang, Fu, Yan-Tao, Sun, Hui
Format: Article
Language:English
Subjects:
Biopsy, Needle
Comparative analysis
Dissection
Health aspects
hypocalcaemia
Hypocalcemia
hypoparathyroidism
Identification
Lymphatic system
parathyroid
Parathyroid glands
Parathyroid hormone
rapid intraoperative parathyroid hormone
Surgeons
Surgery
thyroid
Thyroid cancer
Thyroidectomy
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Summary:Hypoparathyroidism is a frequent and serious complication of thyroid surgery. Identification and preservation of the parathyroid glands are key factors in managing hypoparathyroidism. The aim of the present study was to investigate the efficacy of rapid intraoperative parathyroid hormone (rIO-PTH) assay levels through fine needle aspiration (FNA) in identifying parathyroids as a parameter in thyroid surgery. rIO-PTH assay through FNA and frozen section examination were performed on 194 suspected parathyroids anatomical structures from 50 consecutive patients undergoing thyroidectomy (rIO-PTH group). The association between the rIO-PTH values and histological results were analyzed. Clinical effects were compared between the rIO-PTH and control groups from 50 patients undergoing a similar standard surgery. rIO-PTH levels from 93/194 aspirated anatomical structures certified as parathyroid tissues by histological analysis were demonstrated to have a mean of 3,369 pg/ml (range, 145.2-5,000 pg/ml). These values were significantly increased compared with the mean value of 25.7 pg/ml from non-parathyroids tissues significantly (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2016.3896