Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival

Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regu...

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Bibliographic Details
Published in:Genes & development 2004-10, Vol.18 (19), p.2336-2341
Main Authors: Hock, Hanno, Meade, Eliza, Medeiros, Sarah, Schindler, Jeffrey W, Valk, Peter J M, Fujiwara, Yuko, Orkin, Stuart H
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Cell Survival - physiology
DNA Primers
DNA-Binding Proteins - genetics
DNA-Binding Proteins - physiology
ETS Translocation Variant 6 Protein
Hematopoietic Stem Cells - cytology
Mice
Proto-Oncogene Proteins c-ets
Repressor Proteins - genetics
Repressor Proteins - physiology
Research Communications
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Summary:Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regulator of HSC survival. Following inactivation of Tel/Etv6, HSCs are lost in the adult bone marrow but their progeny are unaffected and transiently sustain blood formation. Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes. Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1239604