Electrical Impedance Myography and Its Applications in Neuromuscular Disorders

Electrical impedance myography (EIM) refers to the specific application of electrical bioimpedance techniques for the assessment of neuromuscular disorders. In EIM, a weak, high-frequency electrical current is applied to a muscle or muscle group of interest and the resulting voltages measured. Among...

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Bibliographic Details
Published in:Neurotherapeutics 2017-01, Vol.14 (1), p.107-118
Main Authors: Sanchez, Benjamin, Rutkove, Seward B.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Electric Impedance
Electromyography
Humans
Mice
Muscle, Skeletal - physiopathology
Neurobiology
Neurology
Neuromuscular Diseases - diagnosis
Neuromuscular Diseases - physiopathology
Neurosciences
Neurosurgery
Rats
Review
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Summary:Electrical impedance myography (EIM) refers to the specific application of electrical bioimpedance techniques for the assessment of neuromuscular disorders. In EIM, a weak, high-frequency electrical current is applied to a muscle or muscle group of interest and the resulting voltages measured. Among its advantages, the technique can be used noninvasively across a variety of disorders and requires limited subject cooperation and evaluator training to obtain accurate and repeatable data. Studies in both animals and human subjects support its potential utility as a primary diagnostic tool, as well as a biomarker for clinical trial or individual patient use. This review begins by providing an overview of the current state and technological advances in electrical impedance myography and its specific application to the study of muscle. We then provide a summary of the clinical and preclinical applications of EIM for neuromuscular conditions, and conclude with an evaluation of ongoing research efforts and future developments.
ISSN:1933-7213
1878-7479
1878-7479
DOI:10.1007/s13311-016-0491-x