Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans

Aging is marked by a collapse of protein homeostasis and deterioration of adaptive stress responses that often lead to disease. During aging, the induction of stress responses decline along with protein quality control. Here, we have shown that the ability to mount an adaptive response by pretreatme...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-02, Vol.72 (2), p.143-151
Main Authors: Raynes, Rachel, Juarez, Crystal, Pomatto, Laura C D, Sieburth, Derek, Davies, Kelvin J A
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Aging
Aging - physiology
Animals
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - physiology
DNA-Binding Proteins - physiology
Homeostasis
Nematodes
Original
Oxidative Stress
Proteasome Endopeptidase Complex - physiology
Proteins
Transcription Factors - physiology
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Summary:Aging is marked by a collapse of protein homeostasis and deterioration of adaptive stress responses that often lead to disease. During aging, the induction of stress responses decline along with protein quality control. Here, we have shown that the ability to mount an adaptive response by pretreatment with minor oxidative stress is abrogated in aged Caenorhabditis elegans We have identified a defect in SKN-1 signaling sensitivity during aging and have also found an aging-related increase in basal proteasome expression and in vitro activity, however, adaptation of the 20S proteasome in response to stress is lost in old animals. Interestingly, increased activation of SKN-1 promotes stress resistance, but is unable to rescue declining adaptation during aging. Our data demonstrate that the aging-dependent decline in SKN-1 signaling negatively impacts adaptation of the 20S proteasome in response to acute oxidative stress.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glw093