Comparative efficacy of oral meloxicam and phenylbutazone in 2 experimental pain models in the horse

The efficacy of oral phenylbutazone [PBZ; 4.4 mg/kg body weight (BW), q12h], a non-selective non-steroidal anti-inflammatory drug (NSAID), and oral meloxicam (MXM; 0.6 mg/kg BW, q24h), a COX-2 selective NSAID, were evaluated in 2 experimental pain models in horses: the adjustable heart bar shoe (HBS...

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Bibliographic Details
Published in:Canadian veterinary journal 2017-02, Vol.58 (2), p.157-167
Main Authors: Banse, Heidi, Cribb, Alastair E
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Female
Horses
Lameness, Animal - drug therapy
Lipopolysaccharides - administration & dosage
Male
Pain - drug therapy
Pain - veterinary
Phenylbutazone - administration & dosage
Scientific
Skin Temperature - drug effects
Synovitis - drug therapy
Synovitis - veterinary
Thiazines - administration & dosage
Thiazoles - administration & dosage
Treatment Outcome
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Summary:The efficacy of oral phenylbutazone [PBZ; 4.4 mg/kg body weight (BW), q12h], a non-selective non-steroidal anti-inflammatory drug (NSAID), and oral meloxicam (MXM; 0.6 mg/kg BW, q24h), a COX-2 selective NSAID, were evaluated in 2 experimental pain models in horses: the adjustable heart bar shoe (HBS) model, primarily representative of mechanical pain, and the lipopolysaccharide-induced synovitis (SYN) model, primarily representative of inflammatory pain. In the HBS model, PBZ reduced multiple indicators of pain compared with the placebo and MXM. Meloxicam did not reduce indicators of pain relative to the placebo. In the SYN model, MXM and PBZ reduced increases in carpal skin temperature compared to the placebo. Meloxicam reduced lameness scores and lameness-induced changes in head movement compared to the placebo and PBZ. Phenylbutazone reduced lameness-induced change in head movement compared to the placebo. Overall, PBZ was more effective than MXM at reducing pain in the HBS model, while MXM was more effective at reducing pain in the SYN model at the oral doses used.
ISSN:0008-5286