Correlation of SASH1 expression and ultrasonographic features in breast cancer

SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association b...

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Bibliographic Details
Published in:OncoTargets and therapy 2017-01, Vol.10, p.271-276
Main Authors: Gong, Xuchu, Wu, Jinna, Wu, Jian, Liu, Jun, Gu, Hailin, Shen, Hao
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Calcification
Care and treatment
Cell adhesion & migration
Cell viability
Cellular proteins
Chinese medicine
Development and progression
Ectopic expression
Gene expression
Genetic aspects
Health aspects
Hospitals
Lymphatic system
Medical prognosis
Metastasis
Original Research
Protein expression
Proteins
Signal transduction
Tumors
Ultrasonic imaging
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Summary:SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SASH1 expression and the ultrasonographic features in breast cancer. A total of 186 patients diagnosed with breast cancer were included in this study. The patients received preoperative ultrasound examination, and the expression of SASH1 was determined using immunohistochemistry methods. Spearman's rank correlation analysis was used to analyze the correlation between SASH1-positive expression and the ultrasonographic features. The positive expression of SASH1 was observed in 63 (33.9%) patients. The positive expression rate of SASH1 was significantly decreased in patients with breast cancer (63/186, 33.9%) compared with controls (
ISSN:1178-6930
1178-6930
DOI:10.2147/ott.s119244