Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV− adults

Highlights • We examined the effects of HIV status and marijuana use on brain structure and neurocognitive function. • For HIV+ and HIV- participants, higher levels of MJ use were associated with smaller volumes in the entorhinal cortex and fusiform gyrus. • When MJ use was 1.43g/week, the HIV+ and...

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Bibliographic Details
Published in:Drug and alcohol dependence 2017-01, Vol.170, p.120-127
Main Authors: Thames, April D, Kuhn, Taylor P, Williamson, Timothy J, Jones, Jacob, Mahmood, Zanjbeel, Hammond, Andrea
Format: Article
Language:English
Subjects:
Adult
Adults
Brain
Brain - diagnostic imaging
Brain - drug effects
Brain structure
Cannabinoids - pharmacology
Cannabis
CD4 antigen
Cognition
Cognition & reasoning
Cognition - drug effects
Cognitive ability
Cognitive functioning
Cortex
Cortex (entorhinal)
Entorhinal cortex
Female
Functional anatomy
Group dynamics
Health risks
HIV
HIV Infections - diagnostic imaging
HIV Infections - psychology
Human immunodeficiency virus
Humans
Immune response
Interactive control
Magnetic Resonance Imaging
Male
Marijuana
Marijuana Smoking - pathology
Marijuana Smoking - psychology
Middle Aged
Neurocognition
Psychiatry
Questionnaires
Structure-function relationships
Substance abuse
Substance use
Viral Load
Young Adult
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Description
Summary:Highlights • We examined the effects of HIV status and marijuana use on brain structure and neurocognitive function. • For HIV+ and HIV- participants, higher levels of MJ use were associated with smaller volumes in the entorhinal cortex and fusiform gyrus. • When MJ use was 1.43g/week, the HIV+ and HIV- did not differ in cognitive function.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2016.11.007