Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study

Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic...

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Bibliographic Details
Published in:BMC medical genetics 2017-01, Vol.18 (1), p.6-6, Article 6
Main Authors: Chittoor, Geetha, Haack, Karin, Mehta, Nitesh R, Laston, Sandra, Cole, Shelley A, Comuzzie, Anthony G, Butte, Nancy F, Voruganti, V Saroja
Format: Article
Language:English
Subjects:
Adolescent
Biomarkers - urine
Child
Children & youth
DNA-Binding Proteins - genetics
Excretion
Female
Genetic aspects
Genetic Variation
Genome-Wide Association Study
Genomes
Genotype & phenotype
Girls
Health aspects
Hispanic American children
Hispanic people
Humans
Male
Measurement
Metabolism
Obesity
Polymorphism, Single Nucleotide
Repressor Proteins - genetics
Rheumatism
Transcription Factors - genetics
Uric acid
Uric Acid - metabolism
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Summary:Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study. We performed a genome-wide association analysis for 24-h urinary excretion measures such as urinary uric acid/urinary creatinine ratio, uric acid clearance, fractional excretion of uric acid, and glomerular load of uric acid in SOLAR, while accounting for non-independence among family members. All renal urate excretion measures were significantly heritable (p
ISSN:1471-2350
1471-2350
DOI:10.1186/s12881-016-0366-3