H-NS: an overarching regulator of the Vibrio cholerae life cycle

Vibrio cholerae has become a model organism for studies connecting virulence, pathogen evolution and infectious disease ecology. The coordinate expression of motility, virulence and biofilm enhances its pathogenicity, environmental fitness and fecal-oral transmission. The histone-like nucleoid struc...

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Bibliographic Details
Published in:Research in microbiology 2017-01, Vol.168 (1), p.16-25
Main Authors: Ayala, Julio C., Silva, Anisia J., Benitez, Jorge A.
Format: Article
Language:English
Subjects:
Bacterial Proteins - metabolism
Biofilms - growth & development
Chromatin - metabolism
DNA-Binding Proteins - metabolism
Gene Expression Regulation, Bacterial
H-NS
Life cycle
Locomotion
Protein Binding
Vibrio cholerae
Vibrio cholerae - genetics
Vibrio cholerae - physiology
Virulence
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Summary:Vibrio cholerae has become a model organism for studies connecting virulence, pathogen evolution and infectious disease ecology. The coordinate expression of motility, virulence and biofilm enhances its pathogenicity, environmental fitness and fecal-oral transmission. The histone-like nucleoid structuring protein negatively regulates gene expression at multiple phases of the V. cholerae life cycle. Here we discuss: (i) the regulatory and structural implications of H-NS chromatin-binding in the two-chromosome cholera bacterium; (ii) the factors that counteract H-NS repression; and (iii) a model for the regulation of the V. cholerae life cycle that integrates H-NS repression, cyclic diguanylic acid signaling and the general stress response.
ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2016.07.007