Aging of Cerebral White Matter

Highlights • White matter changes in normal aging and correlation with age-related functional decline. • Advances in neuroimaging enable detection of age-related macrostructural changes in WM. Example: diffusion tensor imaging (DTI) measures WM integrity. • Aged WM is more susceptible to neurologica...

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Bibliographic Details
Published in:Ageing research reviews 2017-03, Vol.34, p.64-76
Main Authors: Liu, Huan, Yang, Yuanyuan, Xia, Yuguo, Zhu, Wen, Leak, Rehana K, Wei, Zhishuo, Wang, Jianyi, Hu, Xiaoming
Format: Article
Language:English
Subjects:
Aging - pathology
Aging - physiology
Aging - psychology
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Brain Injuries, Traumatic - pathology
Brain Injuries, Traumatic - physiopathology
Disease Progression
Humans
Internal Medicine
Nerve Fibers, Myelinated - pathology
Nerve Fibers, Myelinated - physiology
Neural Conduction - physiology
Neuroglia - pathology
Neuroglia - physiology
Neurology
Parkinson Disease - pathology
Parkinson Disease - physiopathology
Stroke - pathology
Stroke - physiopathology
Synaptic Transmission - physiology
White Matter - pathology
White Matter - physiopathology
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Summary:Highlights • White matter changes in normal aging and correlation with age-related functional decline. • Advances in neuroimaging enable detection of age-related macrostructural changes in WM. Example: diffusion tensor imaging (DTI) measures WM integrity. • Aged WM is more susceptible to neurological disorders (stroke, traumatic brain injury, and neurodegeneration). • Further investigation of age-related changes in WM may provide novel therapeutic strategies.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2016.11.006