An fMRI investigation of the relationship between future imagination and cognitive flexibility

• Published in: Neuropsychologia 2017-01, Vol.95, p.156-172
• Main Authors: Roberts, R.P., Wiebels, K., Sumner, R.L., van Mulukom, V., Grady, C.L., Schacter, D.L., Addis, D.R.
• Format: Article
• Language: English
• Subjects: Analysis of Variance; Autobiographical memory; Brain - physiology; Brain Mapping; Cognitive flexibility; Default mode network; Divergent thinking; Episodic simulation; Executive Function - physiology; Female; Frontoparietal control network; Future thinking; Humans; Imagination - physiology; Least-Squares Analysis; Magnetic Resonance Imaging; Male; Memory, Episodic; Neural Pathways - physiology; Neuropsychological Tests; Reaction Time; Salience network; Thinking - physiology; Young Adult
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2016.11.019

While future imagination is largely considered to be a cognitive process grounded in default mode network activity, studies have shown that future imagination recruits regions in both default mode and frontoparietal control networks. In addition, it has recently been shown that the ability to imagine the future is associated with cognitive flexibility, and that tasks requiring cognitive flexibility result in increased coupling of the default mode network with frontoparietal control and salience networks. In the current study, we investigated the neural correlates underlying the association between cognitive flexibility and future imagination in two ways. First, we experimentally varied the degree of cognitive flexibility required during future imagination by manipulating the disparateness of episodic details contributing to imagined events. To this end, participants generated episodic details (persons, locations, objects) within three social spheres; during fMRI scanning they were presented with sets of three episodic details all taken from the same social sphere (Congruent condition) or different social spheres (Incongruent condition) and required to imagine a future event involving the three details. We predicted that, relative to the Congruent condition, future simulation in the Incongruent condition would be associated with increased activity in regions of the default mode, frontoparietal and salience networks. Second, we hypothesized that individual differences in cognitive flexibility, as measured by performance on the Alternate Uses Task, would correspond to individual differences in the brain regions recruited during future imagination. A task partial least squares (PLS) analysis showed that the Incongruent condition resulted in an increase in activity in regions in salience networks (e.g. the insula) but, contrary to our prediction, reduced activity in many regions of the default mode network (including the hippocampus). A subsequent functional connectivity (within-subject seed PLS) analysis showed that the insula exhibited increased coupling with default mode regions during the Incongruent condition. Finally, a behavioral PLS analysis showed that individual differences in cognitive flexibility were associated with differences in activity in a number of regions from frontoparietal, salience and default-mode networks during both future imagination conditions, further highlighting that the cognitive flexibility underlying future imagination is groun