Sodium selenate treatment mitigates reduction of bone volume following traumatic brain injury in rats

Administration of sodium selenate to rats given traumatic brain injury (TBI) attenuates brain damage and improves long-term behavioural outcomes. We have previously provided evidence that TBI causes bone loss in rats, however the effect of sodium selenate treatment on bone quantity following TBI is...

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Bibliographic Details
Published in:Journal of musculoskeletal & neuronal interactions 2016-12, Vol.16 (4), p.369-376
Main Authors: Brady, R D, Grills, B L, Romano, T, Wark, J D, O'Brien, T J, Shultz, S R, McDonald, S J
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Bone and Bones - drug effects
Brain Injuries, Traumatic - complications
Disease Models, Animal
Male
Original
Random Allocation
Rats
Rats, Long-Evans
Selenic Acid - pharmacology
Tomography, X-Ray Computed
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Summary:Administration of sodium selenate to rats given traumatic brain injury (TBI) attenuates brain damage and improves long-term behavioural outcomes. We have previously provided evidence that TBI causes bone loss in rats, however the effect of sodium selenate treatment on bone quantity following TBI is unknown. Rats were randomly assigned into sham injury or fluid percussion injury (FPI) groups and administered saline or sodium selenate for 12 weeks post-injury. Femora were analysed using histomorphometry, peripheral quantitative computed tomography (pQCT) and biomechanical testing. Distal metaphyseal trabecular bone volume fraction of FPI-selenate rats was higher than FPI-vehicle rats (41.8%; p
ISSN:1108-7161