Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals

Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytokine global profiles produced by distinct populations of leukocytes from healthy Brazilian i...

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Bibliographic Details
Published in:Immunity & ageing 2017-01, Vol.14 (1), p.2-2, Article 2
Main Authors: Silveira-Nunes, Gabriela, Speziali, Elaine, Teixeira-Carvalho, Andréa, Vitelli-Avelar, Danielle M, Sathler-Avelar, Renato, Figueiredo-Soares, Taciana, Silva, Maria Luiza, Peruhype-Magalhães, Vanessa, Chaves, Daniel Gonçalves, Brito-Melo, Gustavo Eustáquio, Cardoso, Glenda Meira, Soares, Eric Bassetti, Elói-Santos, Silvana Maria, Teixeira, Rosângela, Queiroz, Dulciene Magalhães, Corrêa-Oliveira, Rodrigo, Faria, Ana Maria Caetano, Martins-Filho, Olindo Assis
Format: Article
Language:English
Subjects:
Aging
B cells
Cytokines
Health aspects
Neutrophils
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Summary:Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytokine global profiles produced by distinct populations of leukocytes from healthy Brazilian individuals was studied. We analysed frequencies of cytokine-producing lymphocytes and innate immune cells from individuals at several ages spanning a lifetime period (0-85 years). Healthy adult individuals presented a balanced profile suggestive of a mature immune system with equal contributions of both innate and adaptive immunity and of both categories of cytokines (inflammatory and regulatory). In healthy newborns and elderly, innate immune cells, especially neutrophils and NK-cells, contributed the most to a balanced profile of cytokines. Our results support the hypothesis that ageing is not associated with a progressive pro-inflammatory cytokine production by all leukocytes but rather with distinct fluctuations in the frequency of cytokine-producing cells throughout life.
ISSN:1742-4933
1742-4933
DOI:10.1186/s12979-017-0084-5