Endometrial cancer and antidepressants: A nationwide population-based study

To our knowledge, the association between antidepressant exposure and endometrial cancer has not been previously explored. Herein, we aim to investigate the association between antidepressant prescription, including novel antidepressants, and the risk for endometrial cancer in a population-based stu...

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Bibliographic Details
Published in:Medicine (Baltimore) 2016-07, Vol.95 (29), p.e4178-e4178
Main Authors: Lin, Chiao-Fan, Chan, Hsiang-Lin, Hsieh, Yi-Hsuan, Liang, Hsin-Yi, Chiu, Wei-Che, Huang, Kuo-You, Lee, Yena, McIntyre, Roger S., Chen, Vincent Chin-Hung
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antidepressive Agents - therapeutic use
Case-Control Studies
Confounding Factors, Epidemiologic
Endometrial Neoplasms - epidemiology
Female
Humans
Incidence
Middle Aged
Observational Study
Risk Factors
Taiwan - epidemiology
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Summary:To our knowledge, the association between antidepressant exposure and endometrial cancer has not been previously explored. Herein, we aim to investigate the association between antidepressant prescription, including novel antidepressants, and the risk for endometrial cancer in a population-based study.Data for the analysis were derived from National Health Insurance Research Database. We identified 8392 cases with a diagnosis of endometrial cancer and 82,432 matched controls. A conditional logistic regression model was used, with adjusting for potentially confounding variables (e.g., comorbid psychiatric diseases, comorbid physical diseases, and other medications). Risk for endometrial cancer in the population-based study sample was categorized by, and assessed as a function of, antidepressant prescription and cumulative dosage.We report no association between endometrial cancer incidence and antidepressant prescription, including those prescribed either selective serotonin reuptake inhibitors (adjusted odds ratio [OR] = 0.98; 95% confidence interval [CI], 0.84-1.15) or serotonin norepinephrine reuptake inhibitors (adjusted OR = 1.14; 95% CI, 0.76-1.71). We also did not identify an association between higher cumulative doses of antidepressant prescription and endometrial cancer.There was no association between antidepressant prescription and endometrial cancer.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000004178