Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population

Xeroderma pigmentosum group G (XPG) recognizes and excises DNA damage on the 3' side during the DNA repair process. Previous studies indicated that gene polymorphisms may associate with gastric cancer susceptibility, but results were inconsistent. We evaluated the association of five potentiall...

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Published in:Aging (Albany, NY.) NY.), 2016-12, Vol.8 (12), p.3311-3320
Main Authors: Hua, Rui-Xi, Zhuo, Zhen-Jian, Zhu, Jinhong, Jiang, Dan-Hua, Xue, Wen-Qiong, Zhang, Shao-Dan, Zhang, Jiang-Bo, Li, Xi-Zhao, Zhang, Pei-Fen, Jia, Wei-Hua, Shen, Guo-Ping, He, Jing
Format: Article
Language:English
Subjects:
China - epidemiology
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Endonucleases - genetics
Endonucleases - metabolism
Female
Genotype
Humans
Male
Middle Aged
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Polymorphism, Single Nucleotide
Research Paper
Stomach Neoplasms - epidemiology
Stomach Neoplasms - genetics
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Xeroderma pigmentosum group G (XPG) recognizes and excises DNA damage on the 3' side during the DNA repair process. Previous studies indicated that gene polymorphisms may associate with gastric cancer susceptibility, but results were inconsistent. We evaluated the association of five potentially functional polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, and rs873601 G>A) with gastric cancer susceptibility in 1142 gastric cancer cases and 1173 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Overall, no significant association was detected between any of selected polymorphism and gastric cancer risk. However, we found that individuals carrying 3-4 risk genotypes were at significantly higher risk of gastric cancer than those with 0-2 risk genotypes (OR=1.32, 95% CI=1.04-1.68, =0.021). The stratification analysis revealed that the cumulative effect of risk genotypes (3-4 vs. 0-2) on gastric cancer were more prominent among subgroups older than 58 years and men. In conclusion, our results indicated that none of the selected polymorphism could significantly alter gastric cancer susceptibility alone. These polymorphisms might collectively confer increased gastric cancer susceptibility. These findings would be strengthened by larger prospective multicenter studies involving different ethnic populations.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.101119