The Cilium: Cellular Antenna and Central Processing Unit

Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory inputs that are related to the cell cycle, cytoskeleton, proteostasis, and cilia-mediated signaling itself. Ciliogenesis...

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Bibliographic Details
Published in:Trends in cell biology 2017-02, Vol.27 (2), p.126-140
Main Authors: Malicki, Jarema J, Johnson, Colin A
Format: Article
Language:English
Subjects:
actin cytoskeleton
Actin Cytoskeleton - metabolism
Animals
Autophagy
Cell Cycle
Cilia
Cilia - metabolism
ciliogenesis
Cytoskeleton
Digital systems
Eukaryotes
Humans
Logic circuits
mTOR pathway
Organogenesis
Pathology
primary cilium
Proteostasis
Regulatory mechanisms (biology)
Review
Signal Transduction
Signaling
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Summary:Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory inputs that are related to the cell cycle, cytoskeleton, proteostasis, and cilia-mediated signaling itself. Ciliogenesis and cilia maintenance are regulated by reciprocal antagonistic or synergistic influences, often acting in parallel to each other. By receiving parallel inputs, cilia appear to integrate multiple signals into specific outputs and may have functions similar to logic gates of digital systems. Some combinations of input signals appear to impose higher hierarchical control related to the cell cycle. An integrated view of these regulatory inputs will be necessary to understand ciliogenesis and its wider relevance to human biology.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2016.08.002