Comparison of mean radiation dose and dosimetric distribution to tooth-bearing regions of the mandible associated with proton beam radiation therapy and intensity modulated radiation therapy for ipsilateral head and neck tumor

Abstract Objective The purpose of this study is to compare the dosimetric distribution of ipsilateral proton beam radiation therapy (PBRT) to intensity-modulated radiation therapy (IMRT) in the tooth-bearing region of the mandible in patients with head and neck cancer (HNC). Patients and Methods The...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2016-11, Vol.122 (5), p.566-571
Main Authors: Owosho, Adepitan A., B.Ch.D, Yom, SaeHee K., DDS, MPH, Han, Zhiqiang, BS, Sine, Kevin, BS, Lee, Nancy Y., MD, Huryn, Joseph M., DDS, Estilo, Cherry L., DMD
Format: Article
Language:English
Subjects:
Diagnostic Imaging
Female
Head and Neck Neoplasms - diagnostic imaging
Head and Neck Neoplasms - radiotherapy
Humans
Male
Mandible - diagnostic imaging
Mandible - radiation effects
Radiation Injuries - diagnostic imaging
Radiation Injuries - etiology
Radiometry - methods
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated
Surgery
Tumor Burden
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Summary:Abstract Objective The purpose of this study is to compare the dosimetric distribution of ipsilateral proton beam radiation therapy (PBRT) to intensity-modulated radiation therapy (IMRT) in the tooth-bearing region of the mandible in patients with head and neck cancer (HNC). Patients and Methods The mandibular dosimetric distribution of HNC patients treated with ≥60 Gy relative biological equivalent (RBE) PBRT were evaluated. The mean radiation doses were calculated in five regions: Ipsilateral molar, ipsilateral premolar, anterior, contralateral premolar and contralateral molar (CM). The CM was used as reference region for comparative analysis. The mandibular dosimetric distribution of patients treated with PBRT was compared to IMRT patients with similar tumor sites and planning target volumes. Results The mean radiation dose to the contralateral regions was lower in patients treated with PBRT compared to IMRT. The average mean radiation dose to the reference region (CM) in patients treated with PBRT (RBE) vs. IMRT: oropharynx [2.2 Gy vs. 23.2 Gy, P
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2016.07.003