Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug

Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one‐step ring‐opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer...

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Bibliographic Details
Published in:Advanced healthcare materials 2016-08, Vol.5 (15), p.1868-1873
Main Authors: Liu, Jinyao, Pang, Yan, Bhattacharyya, Jayanta, Liu, Wenge, Weitzhandler, Isaac, Li, Xinghai, Chilkoti, Ashutosh
Format: Article
Language:English
Subjects:
anticancer
Cell Line, Tumor
Chemical compounds
Copolymers
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drugs
Esters
Female
Humans
Monomers
nanoparticle
Nanoparticles
Nanoparticles - chemistry
paclitaxel
Paclitaxel - chemistry
Particle Size
Polymerization
prodrug
Prodrugs - chemistry
ring-opening polymerization
Toxicity
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Summary:Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one‐step ring‐opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self‐assembles into well‐defined nanoparticles with tunable size.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201600230