Plasminogen–receptor KT: plasminogen activation and beyond

The cell surface orchestrates plasminogen activation through the concomitant binding of plasminogen and plasminogen activators to specific receptors. In this issue, Miles and colleagues describe their detailed phenotypic characterization of mice deficient in Plg-R KT , a key plasminogen receptor exp...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2017-01, Vol.15 (1), p.150-154
Main Authors: Flick, M. J., Bugge, T. H.
Format: Article
Language:English
Online Access:Get full text
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Summary:The cell surface orchestrates plasminogen activation through the concomitant binding of plasminogen and plasminogen activators to specific receptors. In this issue, Miles and colleagues describe their detailed phenotypic characterization of mice deficient in Plg-R KT , a key plasminogen receptor expressed in numerous tissues, but highly expressed by proinflammatory macrophages. The analysis provides critical and surprising new insights into the biology of this receptor.
ISSN:1538-7933
1538-7836
DOI:10.1111/jth.13541