Intestinal Barrier Disturbances in Haemodialysis Patients: Mechanisms, Consequences, and Therapeutic Options

There is accumulating evidence that the intestinal barrier and the microbiota may play a role in the systemic inflammation present in HD patients. HD patients are subject to a number of unique factors, some related to the HD process and others simply to the uraemic milieu but with common characteris...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-11
Main Authors: Bishop, Nicolette C., Stover, C. M., Graham-Brown, M. P. M., March, D. S., Burton, J. O.
Format: Article
Language:English
Subjects:
Antigens
Colleges & universities
Electrolytes
Enzymes
Female
Gastrointestinal Microbiome
Gram-negative bacteria
Hemodialysis patients
Humans
Infections
Inflammation
Intestines - microbiology
Intestines - physiopathology
Male
Mortality
Peritoneal dialysis
Physiological aspects
Proteins
Renal Dialysis - adverse effects
Renal Dialysis - methods
Review
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Description
Summary:There is accumulating evidence that the intestinal barrier and the microbiota may play a role in the systemic inflammation present in HD patients. HD patients are subject to a number of unique factors, some related to the HD process and others simply to the uraemic milieu but with common characteristic that they can both alter the intestinal barrier and the microbiota. This review is intended to provide an overview of the current methods for measuring such changes in HD patients, the mechanisms behind these changes, and potential strategies that may mitigate these modifications. Lastly, intradialytic exercise is an increasingly employed intervention in HD patients; however the potential implications that this may have for the intestinal barrier are not known; therefore future research directions are also covered.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/5765417