Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study

• Published in: Scientific reports 2017-01, Vol.7 (1), p.41516-41516, Article 41516
• Main Authors: García-Álvarez, Mónica, Berenguer, Juan, Jiménez-Sousa, María A., Pineda-Tenor, Daniel, Aldámiz-Echevarria, Teresa, Tejerina, Francisco, Diez, Cristina, Vázquez-Morón, Sonia, Resino, Salvador
• Format: Article
• Language: English
• Subjects: 2',5'-Oligoadenylate Synthetase - genetics; Adult; Alleles; Biopsy; Coinfection - epidemiology; Coinfection - genetics; Cross-Sectional Studies; Deoxyribonucleic acid; DNA; Female; Fibrosis; Gene Frequency - genetics; Genetic Association Studies; Genetic Predisposition to Disease; Genotyping; Haplotypes - genetics; Hepatitis; Hepatitis C; Hepatitis C, Chronic - epidemiology; Hepatitis C, Chronic - genetics; Heredity; HIV; HIV Infections - epidemiology; HIV Infections - genetics; Human immunodeficiency virus; Humanities and Social Sciences; Humans; Liver; Liver diseases; Male; multidisciplinary; Myxovirus resistance proteins; Myxovirus Resistance Proteins - genetics; Polymorphism, Single Nucleotide - genetics; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep41516

The mechanisms involved in the chronic hepatitis C progression are incompletely understood. The aim was to analyze the association between 2 ′ 5 ′ oligoadenylate synthetase 1,2 and 3 (OAS1-3 ) and myxovirus resistance proteins 1 (Mx1 ) polymorphisms and severity of liver disease in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. We performed a cross-sectional study in 219 patients that underwent a liver biopsy. DNA genotyping for Mx1 (rs469390), OAS1 (rs2285934), OAS2 (rs1293762) and OAS3 (rs2010604) was performed by using GoldenGate assay. The outcome variables ion liver biopsy were: (i) significant fibrosis (F ≥ 2); (ii) moderate activity grade (A ≥ 2). Additive model of inheritance for genetic association test was used. The likelihood of having significant fibrosis (F ≥ 2) was lower in patients carrying OAS2 rs1293762 A allele [adjusted odds ratio (aOR) = 0.51; p = 0.040]. Besides, the likelihood of having moderate activity grade (A ≥ 2) was higher in patients carrying Mx1 rs464397 C allele (aOR = 1.63; p = 0.028) and Mx1 rs469390 G allele (aOR = 1.97; p = 0.005), while it was lower in patients carrying OAS1 rs2285934 A allele (aOR = 0.64; p = 0.039) and OAS2 rs1293762 A allele (aOR = 0.41; p = 0.009). In conclusion, Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis.