Neural Signaling Metabolites May Modulate Energy Use in Hibernation

Despite an epidemic in obesity and metabolic syndrome limited means exist to effect adiposity or metabolic rate other than life style changes. Here we review evidence that neural signaling metabolites may modulate thermoregulatory pathways and offer novel means to fine tune energy use. We extend pri...

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Bibliographic Details
Published in:Neurochemical research 2017-01, Vol.42 (1), p.141-150
Main Authors: Drew, Kelly L., Frare, Carla, Rice, Sarah A.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Body Temperature - physiology
Body Temperature Regulation - physiology
Cell Biology
Energy Metabolism - physiology
Hibernation - physiology
Humans
Neurochemistry
Neurology
Neurons - metabolism
Neurosciences
Original Paper
Signal Transduction - physiology
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Summary:Despite an epidemic in obesity and metabolic syndrome limited means exist to effect adiposity or metabolic rate other than life style changes. Here we review evidence that neural signaling metabolites may modulate thermoregulatory pathways and offer novel means to fine tune energy use. We extend prior reviews on mechanisms that regulate thermogenesis and energy use in hibernation by focusing primarily on the neural signaling metabolites adenosine, AMP and glutamate.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-016-2109-4