TFIID or not TFIID, a continuing transcriptional SAGA

Eukaryotic protein‐coding genes are typically classified into two groups: those with expression regulated by specific signals versus the relatively constant “housekeeping” genes. Although these differences are associated with alternative modes of RNA polymerase II (RNAP II) pre‐initiation complex (P...

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Bibliographic Details
Published in:The EMBO journal 2017-02, Vol.36 (3), p.248-249
Main Authors: Kubik, Slawomir, Bruzzone, Maria Jessica, Shore, David
Format: Article
Language:English
Subjects:
EMBO09
EMBO44
Eukaryotes
Gene expression
Humans
News & Views
Proteins
RNA polymerase
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae Proteins - genetics
TATA-Binding Protein Associated Factors - genetics
Transcription Factor TFIID - genetics
Transcription, Genetic
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Summary:Eukaryotic protein‐coding genes are typically classified into two groups: those with expression regulated by specific signals versus the relatively constant “housekeeping” genes. Although these differences are associated with alternative modes of RNA polymerase II (RNAP II) pre‐initiation complex (PIC) assembly, a role for gene‐specific activators in controlling “regulatability” has been difficult to rule out. To address this question, de Jonge et al ( 2017 ) studied a group of genes controlled by a common activator but dependent on either TFIID or SAGA and found that the magnitude of regulation strongly correlates with the mechanism of PIC assembly. Graphical Abstract Alternative modes of transcriptional pre‐initiation complex assembly rather than gene‐specific activators differentiate housekeeping gene expression from regulated gene expression.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.201696152